Rrp8 ribosomal RNA processing 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rrp8provided by RGD
Official Full Name: ribosomal RNA processing 8provided by RGD
Primary source: RGD:1308302
See related: EnsemblRapid:ENSRNOG00000018766 AllianceGenome:RGD:1308302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308302
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Predicted to act upstream of with a negative effect on regulation of G1 to G0 transition. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and rDNA heterochromatin. Predicted to be part of eNoSc complex. Predicted to be active in nucleolus. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 99.2), Spleen (RPKM 74.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169489829..169500551, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (160081092..160088709, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170574670..170578693, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:224834 (e-PCR)
- UniSTS:224834

AI177038 (e-PCR)
- UniSTS:250221

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rDNA heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in rDNA heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in rDNA heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect regulation of G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by glucose	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by glucose	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by glucose	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin silencing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin silencing complex	ISO Inferred from Sequence Orthology more info
part_of chromatin silencing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of eNoSc complex	IEA Inferred from Electronic Annotation more info
part_of eNoSc complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in rDNA heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in rDNA heterochromatin	IEA Inferred from Electronic Annotation more info
located_in rDNA heterochromatin	ISO Inferred from Sequence Orthology more info
located_in rDNA heterochromatin	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribosomal RNA-processing protein 8

Names: cerebral protein 1 homolog

NP_001008347.1

EC 2.1.1.-

XP_038934098.1

EC 2.1.1.-

XP_063119064.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008346.1 → NP_001008347.1 ribosomal RNA-processing protein 8

See identical proteins and their annotated locations for NP_001008347.1

Status: PROVISIONAL

Source sequence(s)

BC085119

UniProtKB/Swiss-Prot

Q5U4F0

UniProtKB/TrEMBL

A0A8I6ARN6, A6I7L7

Related

ENSRNOP00000025651.5, ENSRNOT00000025651.8

Conserved Domains (2) summary

COG0500
Location:267 → 389

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam05148
Location:243 → 457

Methyltransf_8; Hypothetical methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

169489829..169500551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078170.2 → XP_038934098.1 ribosomal RNA-processing protein 8 isoform X2

Conserved Domains (1) summary

pfam05148
Location:115 → 329

Methyltransf_8; Hypothetical methyltransferase
XM_063262994.1 → XP_063119064.1 ribosomal RNA-processing protein 8 isoform X1

UniProtKB/TrEMBL

A0A8L2QDU0