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    Fuz fuzzy planar cell polarity protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308577, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fuzprovided by RGD
    Official Full Name
    fuzzy planar cell polarity proteinprovided by RGD
    Primary source
    RGD:1310608
    See related
    EnsemblRapid:ENSRNOG00000053084 AllianceGenome:RGD:1310608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310608
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Predicted to act upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regionalization. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 59.8), Brain (RPKM 49.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fuz in Genome Data Viewer
    Location:
    1q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104515782..104524591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95379542..95384532)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100891832..100896811)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene mediator complex subunit 25 Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Seo JH, et al. Hum Mol Genet, 2011 Nov 15. PMID 21840926
    2. The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. Gray RS, et al. Nat Cell Biol, 2009 Oct. PMID 19767740, Free PMC Article
    3. A novel ciliopathic skull defect arising from excess neural crest. Tabler JM, et al. Dev Biol, 2016 Sep 1. PMID 27395007, Free PMC Article
    4. The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Toriyama M, et al. Nat Genet, 2016 Jun. PMID 27158779, Free PMC Article
    5. Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx. Tabler JM, et al. Elife, 2017 Feb 13. PMID 28177282, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125220

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic neurocranium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic skeletal system morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of planar polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of planar polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hair follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within larynx morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neural crest formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neural crest formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spinal cord development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tongue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein fuzzy homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037646.2 → NP_001032735.1  protein fuzzy homolog isoform 2

      See identical proteins and their annotated locations for NP_001032735.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5XV94
      Related
      ENSRNOP00000074982.1, ENSRNOT00000086890.3

    2. NM_001399381.1 → NP_001386310.1  protein fuzzy homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q3B756
      UniProtKB/TrEMBL
      A6JAU2
      Related
      ENSRNOP00000070688.1, ENSRNOT00000083336.3
      Conserved Domains (1) summary
      cd21091
      Location:12 → 413
      Fuzzy; protein fuzzy and homologs

    3. NM_001399382.1 → NP_001386311.1  protein fuzzy homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (1) summary
      cl40581
      Location:12 → 322
      Fuzzy; protein fuzzy and homologs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104515782..104524591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229060.5 → XP_006229122.1  protein fuzzy homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5XV94, A0A8I6ABP8
      Related
      ENSRNOP00000091471.1, ENSRNOT00000114637.2

    2. XM_039112059.2 → XP_038967987.1  protein fuzzy homolog isoform X7

      Conserved Domains (1) summary
      cl40581
      Location:12 → 263
      Fuzzy; protein fuzzy and homologs

    3. XM_063261942.1 → XP_063118012.1  protein fuzzy homolog isoform X4

    4. XM_063261966.1 → XP_063118036.1  protein fuzzy homolog isoform X9

    5. XM_063261949.1 → XP_063118019.1  protein fuzzy homolog isoform X7

    6. XM_039112029.2 → XP_038967957.1  protein fuzzy homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5XV94
      Related
      ENSRNOP00000112429.1, ENSRNOT00000152626.1
      Conserved Domains (1) summary
      cl40581
      Location:12 → 390
      Fuzzy; protein fuzzy and homologs

    7. XM_039112048.2 → XP_038967976.1  protein fuzzy homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I5XV94
      Conserved Domains (1) summary
      cl40581
      Location:12 → 324
      Fuzzy; protein fuzzy and homologs

    8. XM_063261955.1 → XP_063118025.1  protein fuzzy homolog isoform X8

    9. XM_006229061.5 → XP_006229123.1  protein fuzzy homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5XV94

    10. XM_039112046.2 → XP_038967974.1  protein fuzzy homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I5XV94
      Conserved Domains (1) summary
      cl40581
      Location:20 → 332
      Fuzzy; protein fuzzy and homologs

    11. XM_039112064.2 → XP_038967992.1  protein fuzzy homolog isoform X10

      Conserved Domains (1) summary
      cl40581
      Location:1 → 251
      Fuzzy; protein fuzzy and homologs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B756.2 GenPept UniProtKB/Swiss-Prot:Q3B756

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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