notch1a notch receptor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: notch1aprovided by ZNC
Official Full Name: notch receptor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-173
See related: Ensembl:ENSDARG00000103554 AllianceGenome:ZFIN:ZDB-GENE-990415-173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: des; n1a; wu:fc01e02; wu:fc37a05
Summary: Predicted to enable Notch binding activity. Involved in Notch signaling pathway and hematopoietic stem cell differentiation. Acts upstream of or within with a positive effect on regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including cell differentiation in spinal cord; chordate embryonic development; and regulation of cell fate specification. Is active in plasma membrane. Is expressed in several structures, including digestive system; fin; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (4766244..4849029, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (4602559..4684464, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Title: Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2.
Title: Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2.
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h.
Title: Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h.
Notch-Mediated Determination of Hair-Bundle Polarity in Mechanosensory Hair Cells of the Zebrafish Lateral Line.
Title: Notch-Mediated Determination of Hair-Bundle Polarity in Mechanosensory Hair Cells of the Zebrafish Lateral Line.
To clarify the role of Notch signaling in osteogenesis, we established a zebrafish model, in which Notch1a intracellular domain (N1aICD) was specifically expressed in the osteoblasts. We found that overexpression of N1aICD in osteoblasts caused hyperosteogeny in the column region of zebrafish with the morphology of narrowed neural/hemal canals
Title: Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish.
Notch1a plays roles in inhibiting many immunity-related genes and could comprehensively mediate the innate immune response by regulating TLRs, nucleotide-binding-oligomerization-domain-like receptors (NLRs), lectins, complement, ILs, chemokines, TNF, cathepsin, and serpin.
Title: Notch1a can widely mediate innate immune responses in zebrafish larvae infected with Vibrio parahaemolyticus.
Data show that in endothelial cells, bone morphogenetic protein endothelial precursor-derived regulator (BMPER) and twisted gastrulation protein homolog 1 (TWSG1) are necessary for regular Notch signaling activity.
Title: Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells.
Results suggest that Notch signaling regulates glycolysis-related gene expression in a context-dependent manner in neural tissues at different developmental stages.
Title: Notch signaling regulates the expression of glycolysis-related genes in a context-dependent manner during embryonic development.
Notch signalling strength is quantitatively interpreted in different organ systems, and suggest a role for intercellular communication in regulating the output period of the segmentation clock by altering its spatial pattern.
Title: Faster embryonic segmentation through elevated Delta-Notch signalling.
Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue.
Title: Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc01e02.x1 (e-PCR)
- UniSTS:192038

not1 (e-PCR)
- UniSTS:187002

fc37a05.x1 (e-PCR)
- UniSTS:188052

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling involved in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal aorta development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural plate development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of developmental process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of endodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: neurogenic locus notch homolog protein 1

Names: deadly seven; notch 1; notch 1a; notch homolog 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131441.1 → NP_571516.1 neurogenic locus notch homolog protein 1 precursor

See identical proteins and their annotated locations for NP_571516.1

Status: PROVISIONAL

Source sequence(s)

X69088

UniProtKB/Swiss-Prot

P46530

Conserved Domains (9) summary

smart00004
Location:1440 → 1477

NL; Domain found in Notch and Lin-12

cd00054
Location:177 → 215

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1862 → 2003

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1485 → 1520

Notch; LNR domain

pfam06816
Location:1565 → 1616

NOD; NOTCH protein

pfam07684
Location:1664 → 1721

NODP; NOTCH protein

pfam11936
Location:2364 → 2424

DUF3454; Domain of unknown function (DUF3454)

pfam12796
Location:1920 → 2013

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1867 → 1913

ANK; ANK repeat [structural motif]