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    Dok3 docking protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306760, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dok3provided by RGD
    Official Full Name
    docking protein 3provided by RGD
    Primary source
    RGD:1311840
    See related
    EnsemblRapid:ENSRNOG00000013564 AllianceGenome:RGD:1311840
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human DOK3 (docking protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 110.0), Lung (RPKM 37.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dok3 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9114763..9121781)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9109633..9115188)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9639064..9644090)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 193, member B Neighboring gene uncharacterized LOC108348505 Neighboring gene DEAD-box helicase 41 Neighboring gene microRNA 3542 Neighboring gene PDZ and LIM domain 7 Neighboring gene uncharacterized LOC134482675 Neighboring gene drebrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of DOK genes as lung tumor suppressors. Berger AH, et al. Nat Genet, 2010 Mar. PMID 20139980, Free PMC Article
    2. Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Cong F, et al. Mol Cell Biol, 1999 Dec. PMID 10567556, Free PMC Article
    3. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, et al. Anticancer Res, 2016 Jul. PMID 27354594
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 3
    Names
    downstream of tyrosine kinase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107336.1 → NP_001100806.1  docking protein 3

      See identical proteins and their annotated locations for NP_001100806.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474032
      UniProtKB/Swiss-Prot
      B2RYG7
      UniProtKB/TrEMBL
      A0A8I5ZPN8
      Related
      ENSRNOP00000018232.4, ENSRNOT00000018232.6
      Conserved Domains (2) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:9 → 123
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9114763..9121781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276336.1 → XP_063132406.1  docking protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B2RYG7
      Related
      ENSRNOP00000079980.2, ENSRNOT00000112507.2

    2. XM_006253619.5 → XP_006253681.1  docking protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006253681.1

      UniProtKB/Swiss-Prot
      B2RYG7
      UniProtKB/TrEMBL
      A0A8I5ZPN8
      Conserved Domains (2) summary
      cd01203
      Location:157 → 255
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:9 → 123
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RYG7.1 GenPept UniProtKB/Swiss-Prot:B2RYG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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