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    Cobl cordon-bleu WH2 repeat protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305497, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Coblprovided by RGD
    Official Full Name
    cordon-bleu WH2 repeat proteinprovided by RGD
    Primary source
    RGD:1312002
    See related
    EnsemblRapid:ENSRNOG00000004281 AllianceGenome:RGD:1312002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization; collateral sprouting in absence of injury; and positive regulation of cell projection organization. Predicted to act upstream of or within several processes, including chordate embryonic development; liver development; and notochord development. Located in cell cortex and plasma membrane. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 56.4), Liver (RPKM 52.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (91041721..91274272, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86828137..87060682, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (92341949..92497169, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481784 Neighboring gene uncharacterized LOC134481783 Neighboring gene uncharacterized LOC134481785 Neighboring gene uncharacterized LOC102553003 Neighboring gene transfer RNA arginine (anticodon UCU) 6 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development. Izadi M, et al. Elife, 2021 Jul 15. PMID 34264190, Free PMC Article
    2. The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I. Schwintzer L, et al. EMBO J, 2011 Jul 1. PMID 21725280, Free PMC Article
    3. Cordon-bleu is an actin nucleation factor and controls neuronal morphology. Ahuja R, et al. Cell, 2007 Oct 19. PMID 17956734, Free PMC Article
    4. Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Gasca S, et al. Dev Genet, 1995. PMID 7586755
    5. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Hou W, et al. PLoS Biol, 2015. PMID 26334624, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
      Title: Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development.
    2. Cobl is an actin nucleator controlling neuronal morphology and development.
      Title: Cordon-bleu is an actin nucleation factor and controls neuronal morphology.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament network formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament network formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collateral sprouting in absence of injury IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in collateral sprouting in absence of injury ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in digestive tract development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestive tract development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic axis specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in floor plate development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in floor plate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in notochord development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in notochord development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somite specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somite specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in terminal web IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in terminal web ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein cordon-bleu
    Names
    cordon-bleu homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401101.1 → NP_001388030.1  protein cordon-bleu isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K2Q1, A0A8I6AEB0
      Related
      ENSRNOP00000097856.2, ENSRNOT00000105473.2

    2. NM_001401102.1 → NP_001388031.1  protein cordon-bleu isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AEB0, A0A8I6ASN2
      Related
      ENSRNOP00000107957.1, ENSRNOT00000135785.1

    3. NM_001401103.1 → NP_001388032.1  protein cordon-bleu isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AEB0
      Related
      ENSRNOP00000091350.2, ENSRNOT00000110506.2

    4. NM_001401104.1 → NP_001388033.1  protein cordon-bleu isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AEB0

    5. NM_001401105.1 → NP_001388034.1  protein cordon-bleu isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZV00, A0A8I6AEB0
      Related
      ENSRNOP00000063258.2, ENSRNOT00000064483.3

    6. NM_001401106.1 → NP_001388035.1  protein cordon-bleu isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AEB0

    7. NM_001401108.1 → NP_001388037.1  protein cordon-bleu isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AJQ5
      Related
      ENSRNOP00000102446.1, ENSRNOT00000141519.1

    8. NM_001401109.1 → NP_001388038.1  protein cordon-bleu isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AJQ5

    9. NM_001401112.1 → NP_001388041.1  protein cordon-bleu isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AJQ5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      91041721..91274272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092058.2 → XP_038947986.1  protein cordon-bleu isoform X8

      UniProtKB/TrEMBL
      A0A8I6AEB0
      Conserved Domains (4) summary
      pfam09469
      Location:152 → 228
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21799
      Location:1170 → 1202
      WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21800
      Location:1216 → 1256
      WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21801
      Location:1304 → 1329
      WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

    2. XM_039092060.2 → XP_038947988.1  protein cordon-bleu isoform X9

      UniProtKB/TrEMBL
      A0A8I6AEB0
      Conserved Domains (4) summary
      pfam09469
      Location:152 → 228
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21799
      Location:1138 → 1170
      WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21800
      Location:1184 → 1224
      WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21801
      Location:1272 → 1297
      WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

    3. XM_039092053.2 → XP_038947981.1  protein cordon-bleu isoform X5

      UniProtKB/TrEMBL
      A0A8I6AEB0
      Conserved Domains (4) summary
      pfam09469
      Location:152 → 228
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21799
      Location:1195 → 1227
      WH2_Wa_Cobl; first Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wa) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21800
      Location:1241 → 1281
      WH2_Wb_Cobl; second Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wb) found in protein Cordon-Bleu (Cobl) and similar proteins
      cd21801
      Location:1329 → 1354
      WH2_Wc_Cobl; third Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat (called Wc) found in protein Cordon-Bleu (Cobl) and similar proteins

    4. XM_063273232.1 → XP_063129302.1  protein cordon-bleu isoform X10

      UniProtKB/TrEMBL
      A0A8I6AEB0

    5. XM_063273227.1 → XP_063129297.1  protein cordon-bleu isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEB0
      Related
      ENSRNOP00000072330.3, ENSRNOT00000086154.3

    6. XM_063273229.1 → XP_063129299.1  protein cordon-bleu isoform X4

      UniProtKB/TrEMBL
      A0A8I6AEB0

    7. XM_063273230.1 → XP_063129300.1  protein cordon-bleu isoform X6

      UniProtKB/TrEMBL
      A0A8I6AEB0

    8. XM_063273231.1 → XP_063129301.1  protein cordon-bleu isoform X7

      UniProtKB/TrEMBL
      A0A8I6AEB0

    9. XM_039092055.2 → XP_038947983.2  protein cordon-bleu isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEB0

    10. XM_063273228.1 → XP_063129298.1  protein cordon-bleu isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEB0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107236.1: Suppressed sequence

      Description
      NM_001107236.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZUI5.1 GenPept UniProtKB/Swiss-Prot:D3ZUI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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