Klhl24 kelch-like family member 24 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl24provided by RGD
Official Full Name: kelch-like family member 24provided by RGD
Primary source: RGD:727971
See related: EnsemblRapid:ENSRNOG00000033372 AllianceGenome:RGD:727971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dre1
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in intermediate filament organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in adherens junction and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and familial hypertrophic cardiomyopathy. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 826.4), Heart (RPKM 740.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (94348024..94382085, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80843621..80877649, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (84613101..84643674, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel neuronal protein of the BTB/kelch family, KRIP6.
Title: KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of kainate selective glutamate receptor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in desmosome	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch-like protein 24

Names: KRIP6; kainate receptor-interacting protein for GluR6; kelch-like 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394229.1 → NP_001381158.1 kelch-like protein 24

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2, F1LNL5

Related

ENSRNOP00000050815.6, ENSRNOT00000052120.7

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)
NM_181473.3 → NP_852138.2 kelch-like protein 24

See identical proteins and their annotated locations for NP_852138.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2, F1LNL5

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

94348024..94382085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270472.1 → XP_063126542.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2
XM_039088275.2 → XP_038944203.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2, F1LNL5

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)
XM_063270469.1 → XP_063126539.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2
XM_063270473.1 → XP_063126543.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2
XM_063270470.1 → XP_063126540.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2
XM_063270471.1 → XP_063126541.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2
XM_039088276.2 → XP_038944204.1 kelch-like protein 24 isoform X1

UniProtKB/Swiss-Prot

Q56A24, Q812D9

UniProtKB/TrEMBL

A6JSC2, F1LNL5

Conserved Domains (4) summary

smart00612
Location:545 → 591

Kelch; Kelch domain

PHA03098
Location:62 → 566

PHA03098; kelch-like protein; Provisional

sd00038
Location:354 → 393

Kelch; KELCH repeat [structural motif]

cd18253
Location:48 → 168

BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)