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    Wipi1 WD repeat domain, phosphoinositide interacting 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303630, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wipi1provided by RGD
    Official Full Name
    WD repeat domain, phosphoinositide interacting 1provided by RGD
    Primary source
    RGD:1307754
    See related
    EnsemblRapid:ENSRNOG00000003827 AllianceGenome:RGD:1307754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307754
    Summary
    Predicted to enable several functions, including nuclear receptor binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of autophagosome assembly; and vesicle targeting, trans-Golgi to endosome. Predicted to be located in bounding membrane of organelle; phagophore assembly site; and trans-Golgi network. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 179.4), Muscle (RPKM 86.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wipi1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95042451..95079679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94542946..94580174, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97859730..97896949, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene arylsulfatase G Neighboring gene solute carrier family 16, member 6 Neighboring gene 5E5 antigen-like Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene uncharacterized LOC134480894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy. Proikas-Cezanne T, et al. FEBS Lett, 2007 Jul 24. PMID 17618624
    2. WIPI1 is a conserved mediator of right ventricular failure. Tzimas C, et al. JCI Insight, 2019 Apr 25. PMID 31021818, Free PMC Article
    3. PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Jeffries TR, et al. Mol Biol Cell, 2004 Jun. PMID 15020712, Free PMC Article
    4. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Polson HE, et al. Autophagy, 2010 May. PMID 20505359
    5. Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. Devereaux K, et al. PLoS One, 2013. PMID 24098492, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WIPI1 is a conserved mediator of right ventricular failure.
      Title: WIPI1 is a conserved mediator of right ventricular failure.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle targeting, trans-Golgi to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain phosphoinositide-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127297.1 → NP_001120769.1  WD repeat domain phosphoinositide-interacting protein 1

      See identical proteins and their annotated locations for NP_001120769.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166829
      UniProtKB/TrEMBL
      A0A8I5ZTL1, B2RYM2, F1LPN5
      Related
      ENSRNOP00000101117.1, ENSRNOT00000153625.1
      Conserved Domains (2) summary
      sd00039
      Location:144 → 184
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:120 → 352
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      95042451..95079679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768367.3 → XP_008766589.1  WD repeat domain phosphoinositide-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YNM5
      Conserved Domains (3) summary
      COG2319
      Location:38 → 262
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 102
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:18 → 180
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039086173.2 → XP_038942101.1  WD repeat domain phosphoinositide-interacting protein 1 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:31 → 69
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:31 → 147
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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