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    Acsbg2 acyl-CoA synthetase bubblegum family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301120, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acsbg2provided by RGD
    Official Full Name
    acyl-CoA synthetase bubblegum family member 2provided by RGD
    Primary source
    RGD:1588580
    See related
    EnsemblRapid:ENSRNOG00000045947 AllianceGenome:RGD:1588580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable arachidonate-CoA ligase activity and fatty acyl-CoA hydrolase activity. Predicted to be involved in long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 445.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsbg2 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1770971..1802635, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1683846..1715517, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10172317..10203550)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene regulatory factor X2 Neighboring gene uncharacterized LOC120094598 Neighboring gene myosin light chain 12B, pseudogene 2 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene MLLT1, super elongation complex subunit Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Fraisl P, et al. Arch Biochem Biophys, 2006 Jul 1. PMID 16762313
    2. The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase. Pei Z, et al. J Biol Chem, 2006 Mar 10. PMID 16371355
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC156748

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase ACSBG2
    Names
    arachidonate--CoA ligase ACSBG2
    bubblegum-related acyl-CoA synthetase 2
    NP_001073565.1
    XP_006244373.1
    XP_063122895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080096.1 → NP_001073565.1  long-chain-fatty-acid--CoA ligase ACSBG2

      See identical proteins and their annotated locations for NP_001073565.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129110
      UniProtKB/Swiss-Prot
      A1L1K7
      Conserved Domains (1) summary
      cd05933
      Location:69 → 665
      ACSBG_like; Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1770971..1802635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244311.5 → XP_006244373.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

      See identical proteins and their annotated locations for XP_006244373.1

      UniProtKB/TrEMBL
      A6KQU4
      Related
      ENSRNOP00000066937.2, ENSRNOT00000074555.4
      Conserved Domains (2) summary
      COG1022
      Location:78 → 698
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
      cl17068
      Location:100 → 696
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. XM_063266825.1 → XP_063122895.1  long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1

      UniProtKB/TrEMBL
      A6KQU4

    RNA

    1. XR_001839650.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L1K7.1 GenPept UniProtKB/Swiss-Prot:A1L1K7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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