Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clpxprovided by RGD
Official Full Name: caseinolytic mitochondrial matrix peptidase chaperone subunit Xprovided by RGD
Primary source: RGD:1304883
See related: EnsemblRapid:ENSRNOG00000030225 AllianceGenome:RGD:1304883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and peptidase activator activity. Predicted to contribute to ATP-dependent peptidase activity. Predicted to be involved in ATP metabolic process and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol; mitochondrial nucleoid; and nucleoplasm. Predicted to be part of mitochondrial endopeptidase Clp complex. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1351.0), Heart (RPKM 603.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (74700602..74740244)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (65805460..65845643)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (70789137..70843133)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA943580 (e-PCR)
- UniSTS:260663

RH130389 (e-PCR)
- UniSTS:213673

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to ATP-dependent peptidase activity	ISO Inferred from Sequence Orthology more info
contributes_to ATP-dependent peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of endopeptidase Clp complex	ISO Inferred from Sequence Orthology more info
part_of endopeptidase Clp complex	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial endopeptidase Clp complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial endopeptidase Clp complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Names: ClpX caseinolytic peptidase X homolog; ClpX caseinolytic protease X homolog; caseinolytic peptidase X; caseinolytic protease X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007803.2 → NP_001007804.1 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

See identical proteins and their annotated locations for NP_001007804.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q5U2U0

UniProtKB/TrEMBL

A0A8I6A7H5, A6J5E7

Related

ENSRNOP00000088647.2, ENSRNOT00000097161.2

Conserved Domains (4) summary

smart01086
Location:509 → 603

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

TIGR00382
Location:102 → 600

clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)

pfam07724
Location:286 → 502

AAA_2; AAA domain (Cdc48 subfamily)

cl02609
Location:104 → 132

Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

74700602..74740244

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243250.3 → XP_006243312.1 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A7H5

Related

ENSRNOP00000088175.1, ENSRNOT00000103006.2

Conserved Domains (4) summary

smart01086
Location:495 → 589

ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein

TIGR00382
Location:102 → 586

clpX; endopeptidase Clp ATP-binding regulatory subunit (clpX)

pfam07724
Location:272 → 488

AAA_2; AAA domain (Cdc48 subfamily)

cl02609
Location:104 → 132

Zn-ribbon; C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit