Rdh16 retinol dehydrogenase 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rdh16provided by RGD
Official Full Name: retinol dehydrogenase 16provided by RGD
Primary source: RGD:735050
See related: EnsemblRapid:ENSRNOG00000081739 AllianceGenome:RGD:735050
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rdh2; RoDHII
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in positive regulation of retinoic acid biosynthetic process; retinoic acid metabolic process; and retinol metabolic process. Located in endoplasmic reticulum membrane. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65499763..65510304)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63616711..63625053)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71058150..71072685)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 11-cis-retinol dehydrogenase	IEA Inferred from Electronic Annotation more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: retinol dehydrogenase 16

Names: 29 kDa protein; retinol dehydrogenase 16 (all-trans); retinol dehydrogenase 2; retinol dehydrogenase 2-like; retinol dehydrogenase type 1; retinol dehydrogenase type 2; retinol dehydrogenase type II (RODH II)

NP_954678.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

XP_063119217.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.315

EC 1.1.1.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199208.2 → NP_954678.1 retinol dehydrogenase 16

See identical proteins and their annotated locations for NP_954678.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P50170

UniProtKB/TrEMBL

Q6P6V2

Related

ENSRNOP00000039311.4, ENSRNOT00000051075.4

Conserved Domains (2) summary

cd09805
Location:30 → 305

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:30 → 214

adh_short; short chain dehydrogenase