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    Zdhhc22 zinc finger DHHC-type palmitoyltransferase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299211, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zdhhc22provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 22provided by RGD
    Primary source
    RGD:1308446
    See related
    EnsemblRapid:ENSRNOG00000011285 AllianceGenome:RGD:1308446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to act upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC22 (zinc finger DHHC-type palmitoyltransferase 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 52.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc22 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112360051..112377950, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106629090..106646996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111008440..111015695, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene CLOCK-interacting pacemaker Neighboring gene transfer RNA glycine (anticodon ACC) Neighboring gene transmembrane protein 63c Neighboring gene neuroglobin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
    2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC22
    Names
    DHHC-22
    membrane-associated DHHC22 zinc finger protein
    putative palmitoyltransferase ZDHHC22
    zinc finger DHHC domain-containing protein 22
    zinc finger, DHHC domain containing 22
    zinc finger, DHHC-type containing 22
    NP_001034414.1
    XP_038967985.1
    XP_038967986.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039325.2 → NP_001034414.1  palmitoyltransferase ZDHHC22

      See identical proteins and their annotated locations for NP_001034414.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q2TGI8
      UniProtKB/TrEMBL
      A6JE75
      Related
      ENSRNOP00000054651.2, ENSRNOT00000015046.8
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 218
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112360051..112377950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112057.2 → XP_038967985.1  palmitoyltransferase ZDHHC22 isoform X1

      UniProtKB/Swiss-Prot
      Q2TGI8
      UniProtKB/TrEMBL
      A6JE75
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 218
      DHHC; DHHC palmitoyltransferase

    2. XM_039112058.2 → XP_038967986.1  palmitoyltransferase ZDHHC22 isoform X1

      UniProtKB/Swiss-Prot
      Q2TGI8
      UniProtKB/TrEMBL
      A6JE75
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 218
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2TGI8.1 GenPept UniProtKB/Swiss-Prot:Q2TGI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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