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    Miip migration and invasion inhibitory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298643, updated on 2-Nov-2024

    Summary

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    Symbol
    Miipprovided by RGD
    Full Name
    migration and invasion inhibitory proteinprovided by RGD
    Primary source
    RGD:1587376
    See related
    EnsemblRapid:ENSRNOG00000024139 AllianceGenome:RGD:1587376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Iip45
    Summary
    Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of cell migration. Orthologous to human MIIP (migration and invasion inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: GeneIDs 100911456 and 298643 are annotated independently on Rnor_6.0 but may be redundant loci. [06 Feb 2015]
    Expression
    Biased expression in Testes (RPKM 119.7), Thymus (RPKM 109.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Miip in Genome Data Viewer
    Location:
    5q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163575689..163582739, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158292510..158299533, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164672464..164679503, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene reduced expression 2 like 3 Neighboring gene zinc finger protein 933 Neighboring gene mitofusin 2 Neighboring gene uncharacterized LOC134487036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    migration and invasion-inhibitory protein
    Names
    IGFBP-2-Binding Protein, IIp45
    invasion-inhibitory protein 45
    migration and invasion-inhibitory protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017450.2 → NP_001017450.1  migration and invasion-inhibitory protein

      See identical proteins and their annotated locations for NP_001017450.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6AYH0
      Related
      ENSRNOP00000032889.3, ENSRNOT00000035695.7
      Conserved Domains (1) summary
      pfam15734
      Location:48 → 379
      MIIP; Migration and invasion-inhibitory

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      163575689..163582739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287475.1 → XP_063143545.1  migration and invasion-inhibitory protein isoform X1

      Related
      ENSRNOP00000101624.1, ENSRNOT00000160762.1

    2. XM_006239379.4 → XP_006239441.1  migration and invasion-inhibitory protein isoform X2

      See identical proteins and their annotated locations for XP_006239441.1

      UniProtKB/Swiss-Prot
      Q6AYH0
      UniProtKB/TrEMBL
      C0KL24
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 381
      MIIP; Migration and invasion-inhibitory

    3. XM_063287479.1 → XP_063143549.1  migration and invasion-inhibitory protein isoform X1

    4. XM_006239381.4 → XP_006239443.1  migration and invasion-inhibitory protein isoform X2

      See identical proteins and their annotated locations for XP_006239443.1

      UniProtKB/Swiss-Prot
      Q6AYH0
      UniProtKB/TrEMBL
      C0KL24
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 381
      MIIP; Migration and invasion-inhibitory

    5. XM_006239380.5 → XP_006239442.1  migration and invasion-inhibitory protein isoform X2

      See identical proteins and their annotated locations for XP_006239442.1

      UniProtKB/Swiss-Prot
      Q6AYH0
      UniProtKB/TrEMBL
      C0KL24
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 381
      MIIP; Migration and invasion-inhibitory

    6. XM_063287474.1 → XP_063143544.1  migration and invasion-inhibitory protein isoform X1

    7. XM_063287478.1 → XP_063143548.1  migration and invasion-inhibitory protein isoform X1

    8. XM_063287476.1 → XP_063143546.1  migration and invasion-inhibitory protein isoform X1

    9. XM_063287477.1 → XP_063143547.1  migration and invasion-inhibitory protein isoform X1

    10. XM_039109695.2 → XP_038965623.1  migration and invasion-inhibitory protein isoform X2

      UniProtKB/Swiss-Prot
      Q6AYH0
      UniProtKB/TrEMBL
      C0KL24
      Conserved Domains (1) summary
      pfam15734
      Location:42 → 381
      MIIP; Migration and invasion-inhibitory

    11. XM_063287480.1 → XP_063143550.1  migration and invasion-inhibitory protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYH0.2 GenPept UniProtKB/Swiss-Prot:Q6AYH0

    Gene LinkOut

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