Trmt10b tRNA methyltransferase 10B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trmt10bprovided by RGD
Official Full Name: tRNA methyltransferase 10Bprovided by RGD
Primary source: RGD:1310735
See related: EnsemblRapid:ENSRNOG00000012454 AllianceGenome:RGD:1310735
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rg9mtd3
Summary: Predicted to enable tRNA (guanosine(9)-N1)-methyltransferase activity and tRNA binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane and tRNA N1-guanine methylation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in nucleoplasm. Orthologous to human TRMT10B (tRNA methyltransferase 10B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 50.4), Brain (RPKM 48.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (64344491..64368175)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (59548845..59572529)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (60841517..60866480)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tRNA (guanosine(9)-N1)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanosine(9)-N1)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
involved_in tRNA N1-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex	IEA Inferred from Electronic Annotation more info
part_of TIM22 mitochondrial import inner membrane insertion complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA methyltransferase 10 homolog B

Names: RNA (guanine-9-) methyltransferase domain containing 3; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B

NP_001013108.1

EC 2.1.1.221

XP_006238104.1

EC 2.1.1.221

XP_006238105.1

EC 2.1.1.221

XP_006238106.1

EC 2.1.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.