Xkr4 XK related 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xkr4provided by RGD
Official Full Name: XK related 4provided by RGD
Primary source: RGD:1549780
See related: EnsemblRapid:ENSRNOG00000027276 AllianceGenome:RGD:1549780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: XRG4
Summary: Predicted to enable phospholipid scramblase activity and protein homodimerization activity. Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be active in plasma membrane. Orthologous to human XKR4 (XK related 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 123.9), Lung (RPKM 40.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (20694433..21095350)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (15896818..16297733)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (15746012..16141059, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048033 (e-PCR)
- UniSTS:109939

AU026647 (e-PCR)
- UniSTS:114075

RH131924 (e-PCR)
- UniSTS:215207

AI196452 (e-PCR)
- UniSTS:178658

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process involved in development	IBA Inferred from Biological aspect of Ancestor more info
involved_in engulfment of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine exposure on apoptotic cell surface	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on apoptotic cell surface	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: XK-related protein 4

Names: X Kell blood group precursor related family member 4; X-linked Kx blood group related 4; XK, Kell blood group complex subunit-related family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011971.2 → NP_001011971.2 XK-related protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q5GH59

UniProtKB/TrEMBL

A0A8L2QFT8

Related

ENSRNOP00000108539.1, ENSRNOT00000147607.1

Conserved Domains (1) summary

pfam09815
Location:111 → 513

XK-related; XK-related protein