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    Ccdc174 coiled-coil domain containing 174 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297458, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc174provided by RGD
    Official Full Name
    coiled-coil domain containing 174provided by RGD
    Primary source
    RGD:1305225
    See related
    EnsemblRapid:ENSRNOG00000010090 AllianceGenome:RGD:1305225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305225
    Summary
    Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human CCDC174 (coiled-coil domain containing 174). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 123.5), Lung (RPKM 93.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc174 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (125949203..125976179)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124392183..124419035)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123760708..123787529)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548902 Neighboring gene solute carrier family 6 member 6 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ribosomal protein S11, pseudogene 14 Neighboring gene uncharacterized LOC102554857 Neighboring gene similar to human chromosome 3 open reading frame 20 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC134486612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDC174, a novel component of the exon junction complex whose mutation underlies a syndrome of hypotonia and psychomotor developmental delay. Volodarsky M, et al. Hum Mol Genet, 2015 Nov 15. PMID 26358778
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93974

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 174
    Names
    uncharacterized protein C3orf19 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009659.2 → NP_001009659.2  coiled-coil domain-containing protein 174

      See identical proteins and their annotated locations for NP_001009659.2

      Status: VALIDATED

      Source sequence(s)
      BC087050, BE106912, CA334689
      UniProtKB/Swiss-Prot
      Q5PQS7
      UniProtKB/TrEMBL
      A6IBB3, G3V7A6
      Related
      ENSRNOP00000013498.4, ENSRNOT00000013498.7
      Conserved Domains (1) summary
      pfam13300
      Location:238 → 311
      DUF4078; Domain of unknown function (DUF4078)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      125949203..125976179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236907.5 → XP_006236969.1  coiled-coil domain-containing protein 174 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQS7
      Conserved Domains (1) summary
      pfam13300
      Location:238 → 311
      DUF4078; Domain of unknown function (DUF4078)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQS7.2 GenPept UniProtKB/Swiss-Prot:Q5PQS7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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