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    Cercam cerebral endothelial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296616, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cercamprovided by RGD
    Official Full Name
    cerebral endothelial cell adhesion moleculeprovided by RGD
    Primary source
    RGD:1304778
    See related
    EnsemblRapid:ENSRNOG00000026604 AllianceGenome:RGD:1304778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ceecam1
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human CERCAM (cerebral endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 21.7), Uterus (RPKM 20.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cercam in Genome Data Viewer
    Location:
    3p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33515513..33553817)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13118150..13155960)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8421116..8444743)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 4 Neighboring gene ubiquitin related modifier 1 Neighboring gene uncharacterized LOC120101515 Neighboring gene microRNA 219-2 Neighboring gene microRNA 2964 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene GLE1 RNA export mediator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. Starzyk RM, et al. J Infect Dis, 2000 Jan. PMID 10608765
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables procollagen galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable inactive glycosyltransferase 25 family member 3
    Names
    cerebral endothelial cell adhesion molecule 1
    glycosyltransferase 25 family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415688.1 → NP_001402617.1  probable inactive glycosyltransferase 25 family member 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2RBI3, A6JTS9
      Related
      ENSRNOP00000075363.2, ENSRNOT00000090440.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33515513..33553817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283485.1 → XP_063139555.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5U309

    2. XM_063283487.1 → XP_063139557.1  probable inactive glycosyltransferase 25 family member 3 isoform X3

    3. XM_063283488.1 → XP_063139558.1  probable inactive glycosyltransferase 25 family member 3 isoform X3

      Related
      ENSRNOP00000109487.1, ENSRNOT00000158082.1

    4. XM_017591646.3 → XP_017447135.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5U309
      UniProtKB/TrEMBL
      A0A0H2UI04
      Conserved Domains (1) summary
      cd06532
      Location:298 → 480
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    5. XM_063283486.1 → XP_063139556.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5U309
      Related
      ENSRNOP00000112333.1, ENSRNOT00000131573.1

    6. XM_006233769.5 → XP_006233831.1  probable inactive glycosyltransferase 25 family member 3 isoform X1

      See identical proteins and their annotated locations for XP_006233831.1

      UniProtKB/Swiss-Prot
      Q5U309
      UniProtKB/TrEMBL
      A0A0H2UI04
      Related
      ENSRNOP00000057689.4, ENSRNOT00000060969.5
      Conserved Domains (1) summary
      cd06532
      Location:298 → 480
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    7. XM_006233771.5 → XP_006233833.1  probable inactive glycosyltransferase 25 family member 3 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UI04
      Conserved Domains (2) summary
      cd06532
      Location:277 → 459
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
      cl11394
      Location:38 → 82
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    8. XM_039104737.2 → XP_038960665.1  probable inactive glycosyltransferase 25 family member 3 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UI04
      Conserved Domains (1) summary
      cd06532
      Location:243 → 425
      Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

    9. XM_063283489.1 → XP_063139559.1  probable inactive glycosyltransferase 25 family member 3 isoform X4

    RNA

    1. XR_010064603.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001011962.1: Suppressed sequence

      Description
      NM_001011962.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U309.2 GenPept UniProtKB/Swiss-Prot:Q5U309

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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