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    Camsap1 calmodulin regulated spectrin-associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296580, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Camsap1provided by RGD
    Official Full Name
    calmodulin regulated spectrin-associated protein 1provided by RGD
    Primary source
    RGD:1565022
    See related
    EnsemblRapid:ENSRNOG00000017883 AllianceGenome:RGD:1565022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565022
    Summary
    Enables calmodulin binding activity and spectrin binding activity. Involved in neuron projection development. Predicted to be located in microtubule. Predicted to colocalize with microtubule minus-end. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CAMSAP1 (calmodulin regulated spectrin associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 131.2), Testes (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camsap1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29144318..29206382, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8746176..8806067, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3373971..3434027, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene potassium sodium-activated channel subfamily T member 1 Neighboring gene ribosomal protein L8, pseudogene 7 Neighboring gene PIH1 domain containing 1, pseudogene 1 Neighboring gene UBA domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1. Qiao Y, et al. Int Heart J, 2024. PMID 38825498
    2. A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth. King MD, et al. J Neurochem, 2014 Feb. PMID 24117850, Free PMC Article
    3. The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. Baines AJ, et al. Mol Biol Evol, 2009 Sep. PMID 19508979
    4. Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Jiang K, et al. Dev Cell, 2014 Feb 10. PMID 24486153
    5. Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin. Hendershott MC, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24706919, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.
      Title: MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1.
    2. CAMSAP-conserved region represents a functional region of CAMSAP1, which links spectrin-binding to neurite outgrowth
      Title: A conserved sequence in calmodulin regulated spectrin-associated protein 1 links its interaction with spectrin and calmodulin to neurite outgrowth.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule minus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spectrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with microtubule minus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule minus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-regulated spectrin-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168549.2 → NP_001162021.1  calmodulin-regulated spectrin-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001162021.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      D3Z8E6
      UniProtKB/TrEMBL
      A0A0G2K5T1
      Related
      ENSRNOP00000024163.6, ENSRNOT00000024163.9
      Conserved Domains (5) summary
      smart01051
      Location:1465 → 1593
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:248 → 331
      CAMSAP_CH; CAMSAP CH domain
      pfam15346
      Location:1278 → 1355
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:880 → 938
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl21478
      Location:1276 → 1357
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_001415687.1 → NP_001402616.1  calmodulin-regulated spectrin-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZW13
      Related
      ENSRNOP00000081912.1, ENSRNOT00000099628.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29144318..29206382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233672.5 → XP_006233734.1  calmodulin-regulated spectrin-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K5T1
      Conserved Domains (5) summary
      smart01051
      Location:1455 → 1583
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:239 → 322
      CAMSAP_CH; CAMSAP CH domain
      pfam15346
      Location:1269 → 1346
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:871 → 929
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl21478
      Location:1267 → 1348
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. XM_006233674.5 → XP_006233736.1  calmodulin-regulated spectrin-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K5T1
      Conserved Domains (5) summary
      smart01051
      Location:1444 → 1572
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:228 → 311
      CAMSAP_CH; CAMSAP CH domain
      pfam15346
      Location:1258 → 1335
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:860 → 918
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl21478
      Location:1256 → 1337
      ATP-synt_B; ATP synthase B/B' CF(0)

    3. XM_063283467.1 → XP_063139537.1  calmodulin-regulated spectrin-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZW13

    4. XM_006233675.5 → XP_006233737.1  calmodulin-regulated spectrin-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5T1, A0A8I6GHB0
      Related
      ENSRNOP00000088653.1, ENSRNOT00000101799.2
      Conserved Domains (5) summary
      smart01051
      Location:1456 → 1584
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam11971
      Location:239 → 322
      CAMSAP_CH; CAMSAP CH domain
      pfam15346
      Location:1269 → 1346
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:871 → 929
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl21478
      Location:1267 → 1348
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. XM_039104722.2 → XP_038960650.1  calmodulin-regulated spectrin-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K5T1
      Conserved Domains (5) summary
      PTZ00121
      Location:1059 → 1231
      PTZ00121; MAEBL; Provisional
      pfam11971
      Location:119 → 202
      CAMSAP_CH; CAMSAP CH domain
      pfam08683
      Location:1337 → 1455
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam15346
      Location:1149 → 1226
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:751 → 809
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

    6. XM_039104723.2 → XP_038960651.1  calmodulin-regulated spectrin-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K5T1
      Conserved Domains (5) summary
      PTZ00121
      Location:891 → 1063
      PTZ00121; MAEBL; Provisional
      smart01051
      Location:1168 → 1296
      CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated
      pfam15346
      Location:981 → 1058
      ARGLU; Arginine and glutamate-rich 1
      pfam17095
      Location:583 → 641
      CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
      cl00030
      Location:1 → 34
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z8E6.2 GenPept UniProtKB/Swiss-Prot:D3Z8E6

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