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    Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29640, updated on 2-Nov-2024

    Summary

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    Symbol
    Dpm2provided by RGD
    Full Name
    dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by RGD
    Primary source
    RGD:2514
    See related
    EnsemblRapid:ENSRNOG00000084654 AllianceGenome:RGD:2514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme regulator activity. Acts upstream of or within GPI anchor biosynthetic process and dolichol metabolic process. Located in endoplasmic reticulum and perinuclear region of cytoplasm. Part of dolichol-phosphate-mannose synthase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 116.0), Brain (RPKM 113.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpm2 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36253548..36256592)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15855952..15858867)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11587941..11590528)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import inner membrane translocase subunit Tim17-B-like Neighboring gene uncharacterized LOC134486072 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda Y, et al. EMBO J, 2000 Jun 1. PMID 10835346, Free PMC Article
    2. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. Maeda Y, et al. EMBO J, 1998 Sep 1. PMID 9724629, Free PMC Article
    3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
    4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within dolichol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dolichol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dolichol-phosphate-mannose synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dolichol-phosphate-mannose synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dolichol-phosphate-mannose synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dolichol phosphate-mannose biosynthesis regulatory protein
    Names
    DPM synthase subunit 2
    dolichol-phosphate (beta-D) mannosyltransferase 2
    dolichol-phosphate mannose synthase subunit 2
    dolichol-phosphate mannosyltransferase 2
    dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
    NP_062125.1
    XP_063139484.1
    XP_063139485.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019252.2 → NP_062125.1  dolichol phosphate-mannose biosynthesis regulatory protein

      See identical proteins and their annotated locations for NP_062125.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9Z325
      UniProtKB/TrEMBL
      A0A8I6AHS9
      Related
      ENSRNOP00000104528.1, ENSRNOT00000131121.1
      Conserved Domains (1) summary
      pfam07297
      Location:5 → 78
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36253548..36256592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283414.1 → XP_063139484.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform X1

    2. XM_063283415.1 → XP_063139485.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z325.3 GenPept UniProtKB/Swiss-Prot:Q9Z325

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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