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    Timm44 translocase of inner mitochondrial membrane 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29635, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Timm44provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 44provided by RGD
    Primary source
    RGD:3864
    See related
    EnsemblRapid:ENSRNOG00000001058 AllianceGenome:RGD:3864
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chaperone binding activity and enzyme binding activity. Involved in cardiac muscle cell differentiation; intracellular protein transport; and response to 3,3',5-triiodo-L-thyronine. Located in mitochondrial inner membrane. Biomarker of diabetic retinopathy. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 430.7), Kidney (RPKM 319.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (7410424..7428179, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (2612581..2629374, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2517006..2533707)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095870 Neighboring gene small nuclear RNA activating complex, polypeptide 2 Neighboring gene cortexin 1 Neighboring gene ELAV like RNA binding protein 1 Neighboring gene uncharacterized LOC102552452 Neighboring gene C-C motif chemokine ligand 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Zhong Q, et al. Invest Ophthalmol Vis Sci, 2011 Nov 7. PMID 22003103, Free PMC Article
    2. Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. Matsuoka T, et al. Diabetes, 2005 Oct. PMID 16186389
    3. Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway. Colavecchia M, et al. Am J Physiol Endocrinol Metab, 2003 Jan. PMID 12388124
    4. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM, et al. Diabetes Metab Res Rev, 2013 Mar. PMID 23255365, Free PMC Article
    5. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N, et al. J Biochem, 1998 Apr. PMID 9538267

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit TIM44
    Names
    translocator of inner mitochondrial membrane 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017267.3 → NP_058963.2  mitochondrial import inner membrane translocase subunit TIM44

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      O35094
      UniProtKB/TrEMBL
      A6KQ73, G3V640
      Related
      ENSRNOP00000001409.4, ENSRNOT00000001409.6
      Conserved Domains (1) summary
      TIGR00984
      Location:66 → 443
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      7410424..7428179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089299.2 → XP_038945227.1  mitochondrial import inner membrane translocase subunit TIM44 isoform X1

      Conserved Domains (1) summary
      TIGR00984
      Location:66 → 258
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35094.1 GenPept UniProtKB/Swiss-Prot:O35094

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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