Rxfp1 relaxin family peptide receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rxfp1provided by RGD
Official Full Name: relaxin family peptide receptor 1provided by RGD
Primary source: RGD:1302973
See related: EnsemblRapid:ENSRNOG00000024120 AllianceGenome:RGD:1302973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lgr7
Summary: Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 123.6), Heart (RPKM 37.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q33

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (167070414..167191616, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (164772270..164893484, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (178402411..178520213, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
Title: Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin.
Title: Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
Results suggest that changes in relaxin family peptides (RXFP3, RXFP1) may contribute to the significant sex differences observed in the hippocampus and amygdala as a function of aging
Title: Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats.
Data indicate that knee passive range of motion (ROM), relaxin receptor isoforms Rxfp1 and Rxfp2 expression were significantly reduced following treatment with testosterone, and androgen antagonist flutamide antagonized the testosterone effect.
Title: Testosterone reduces knee passive range of motion and expression of relaxin receptor isoforms via 5α-dihydrotestosterone and androgen receptor binding.
RXFP1 & RXFP2 up-regulation by progesterone and estrogen could provide the basis for the reported increase in knee laxity while down-regulation of these receptor isoforms by testosterone could explain low incidence of non-contact knee injury in male.
Title: Sex-steroid regulation of relaxin receptor isoforms (RXFP1 & RXFP2) expression in the patellar tendon and lateral collateral ligament of female WKY rats.
RXFP1 was predominantly localized to the tunica media vascular smooth muscle cells in the uterine artery. Highest expression of Rxfp1 in the uterine artery occurred in estrus and early pregnancy.
Title: Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.
H3 relaxin exerts antifibrotic actions via RXFP1 receptor
Title: H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
investigation of expression of RXFP1 in uterine tissues before, during, and after pregnancy; fetal-placental unit appears involved in regulation of expression of RXFP1; down-regulation of RXFP1 expression occurs in late gestation
Title: Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially mediated by the presence of the conceptus.
investigation of expression of RXFP1 in myometrium during gestation; the down-regulation of RXFP1 expression that occurs in late gestation correlates well with progesterone withdrawal
Title: Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats.
Uncovered is a pre-assembled, constitutively active G-protein-coupled receptor signalosome, that couples the relaxin receptor, relaxin family peptide receptor 1 (RXFP1), to cAMP following receptor stimulation with sub-picomolar concentrations of peptide.
Title: Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in lung connective tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung connective tissue development	ISO Inferred from Sequence Orthology more info
involved_in myofibroblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myofibroblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in nipple morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nipple morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in parturition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within parturition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: relaxin receptor 1

Names: leucine-rich repeat-containing G-protein coupled receptor 7; relaxin/insulin-like family peptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201417.2 → NP_958820.2 relaxin receptor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000081726.1, ENSRNOT00000101813.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

167070414..167191616 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232508.5 → XP_006232570.1 relaxin receptor 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVM0

Conserved Domains (5) summary

cd00112
Location:33 → 68

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00116
Location:138 → 356

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:134 → 157

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:427 → 686

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:158 → 216

LRR_8; Leucine rich repeat
XM_039102022.2 → XP_038957950.1 relaxin receptor 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZVM0

Conserved Domains (6) summary

cd00112
Location:33 → 68

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

sd00033
Location:134 → 157

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:278 → 337

LRR_8; Leucine rich repeat

cd14964
Location:413 → 439

7tm_GPCRs; TM helix 1 [structural motif]

cd21340
Location:117 → 287

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl28897
Location:412 → 698

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039102024.2 → XP_038957952.1 relaxin receptor 1 isoform X3

UniProtKB/TrEMBL

A6J5S4, F1M7X9

Conserved Domains (5) summary

sd00033
Location:2 → 22

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:191 → 244

LRR_8; Leucine rich repeat

cd14964
Location:278 → 304

7tm_GPCRs; TM helix 1 [structural motif]

cd21340
Location:2 → 205

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl28897
Location:277 → 563

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily