Rgs4 regulator of G-protein signaling 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs4provided by RGD
Official Full Name: regulator of G-protein signaling 4provided by RGD
Primary source: RGD:3567
See related: EnsemblRapid:ENSRNOG00000002773 AllianceGenome:RGD:3567
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 760.9), Adrenal (RPKM 271.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (84469593..84475884, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (81936775..81943103, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (88054817..88061108, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
Title: The roles of ubiquitin-proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure.
Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
Title: Synergistic regulation of Rgs4 mRNA by HuR and miR-26/RISC in neurons.
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Title: LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling
Title: Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
Title: Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
Data suggest that RGS4 proteins play an important pathophysiological role in the development and expression of l-DOPA-induced dyskinesia
Title: RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.
partial agonism of the M2 muscarinic receptor is regulated by the RGS4-mediated inhibition of G-protein signalling
Title: RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
Tra2beta regulates the expression of RGS4 gene and is induced by morphine.
Title: Splicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphine.
Rgs4 transcript is readily detected but does not respond to hypoxia. Furthermore, this regulation was found to be dependent on transcription, and occurs in a manner consistent with direct HIF transactivation of Rgs4 transcription
Title: Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway.
data demonstrate that RGS4 in the dorsal striatum attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function
Title: RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142220 (e-PCR)
- UniSTS:231470

RH140719 (e-PCR)
- UniSTS:222785

RH141357 (e-PCR)
- UniSTS:223353

RH133702 (e-PCR)
- UniSTS:216985

MARC_16101-16102:1018026133:1 (e-PCR)
- UniSTS:267960

AA004315 (e-PCR), detects polymorphism
- UniSTS:143034

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal root ganglion development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glycine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 4

Names: RGP4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017214.2 → NP_058910.1 regulator of G-protein signaling 4

See identical proteins and their annotated locations for NP_058910.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P49799

UniProtKB/TrEMBL

A0A8I5Y8W6, A6IDM9

Related

ENSRNOP00000003774.2, ENSRNOT00000003774.4

Conserved Domains (1) summary

cd08714
Location:63 → 176

RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein