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    Celf2 CUGBP, Elav-like family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29428, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Celf2provided by RGD
    Official Full Name
    CUGBP, Elav-like family member 2provided by RGD
    Primary source
    RGD:68347
    See related
    EnsemblRapid:ENSRNOG00000023661 AllianceGenome:RGD:68347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Etr3; Napor; Cugbp2; Brunol3
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in post-transcriptional gene silencing. Predicted to be located in Flemming body and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 283.6), Spleen (RPKM 168.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Celf2 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (75813928..76639300)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (70904462..71729072)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (75259269..75660154)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 16 Neighboring gene small nuclear ribonucleoprotein polypeptide E, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102547255 Neighboring gene uncharacterized LOC134482740 Neighboring gene uncharacterized LOC108348587 Neighboring gene uncharacterized LOC134482604 Neighboring gene uncharacterized LOC134482603

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol. Del Pino Sans J, et al. Neuroscience, 2015 Sep 10. PMID 26166732
    2. A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules. Moraes KC, et al. Cell Biol Int, 2013 Oct. PMID 23661609
    3. Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain. Levers TE, et al. Mech Dev, 2002 Mar. PMID 11850193
    4. NAPOR-3 RNA binding protein is required for apoptosis in hippocampus. Pacini A, et al. Brain Res Mol Brain Res, 2005 Oct 31. PMID 16095752
    5. Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases. Xu K, et al. J Biol Chem, 2007 Nov 9. PMID 17855367

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that Cugbp2 regulates splicing and translation of mRNAs linked to sexual differentiation in rats.
      Title: Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol.
    2. a regulatory connection between COX-2 and CUGBP2 in the cardiac cells, was demonstrated.
      Title: A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules.
    3. NAPOR-3 gene overexpression is necessary for the execution of oxygen glucose deprivation-induced programmed cell death.
      Title: NAPOR-3 RNA binding protein is required for apoptosis in hippocampus.
    4. These findings identify a novel paradigm for RNA binding proteins such as CUGBP2 in facilitating opposing functions of mRNA stability and translation inhibition and reveal a mechanism for inhibiting cyclooxygenase-2 expression in cancer cells.
      Title: Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
    5. Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain
      Title: Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.
    6. tissue-specific distribution of NAPOR, CUG-BP, and other highly related proteins within the nervous system
      Title: Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lncRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splice site recognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 2
    Names
    CUG triplet repeat, RNA binding protein 2
    CUG-BP- and ETR-3-like factor 2
    Cugbp- and Etr3-like factor 2
    RNA-binding protein BRUNOL-3
    RNA-binding protein Brunol3
    bruno-like protein 3
    elav-type RNA-binding protein 3
    neuroblastoma apoptosis-related RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083586.3 → NP_001077055.2  CUGBP Elav-like family member 2 isoform 2

      See identical proteins and their annotated locations for NP_001077055.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      A1L1J5, O88756, Q78ZF0, Q792H5
      UniProtKB/TrEMBL
      A6JLW4
      Related
      ENSRNOP00000110458.1, ENSRNOT00000149233.1
      Conserved Domains (3) summary
      cd12638
      Location:434 → 525
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:57 → 140
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:149 → 229
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    2. NM_017197.4 → NP_058893.2  CUGBP Elav-like family member 2 isoform 1

      See identical proteins and their annotated locations for NP_058893.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      A1L1J5, O88756, Q78ZF0, Q792H5
      Related
      ENSRNOP00000077512.2, ENSRNOT00000106925.2
      Conserved Domains (3) summary
      cd12638
      Location:440 → 531
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:57 → 140
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:149 → 229
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      75813928..76639300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276301.1 → XP_063132371.1  CUGBP Elav-like family member 2 isoform X13

    2. XM_063276302.1 → XP_063132372.1  CUGBP Elav-like family member 2 isoform X15

    3. XM_063276304.1 → XP_063132374.1  CUGBP Elav-like family member 2 isoform X17

    4. XM_063276305.1 → XP_063132375.1  CUGBP Elav-like family member 2 isoform X17

    5. XM_063276307.1 → XP_063132377.1  CUGBP Elav-like family member 2 isoform X20

    6. XM_063276308.1 → XP_063132378.1  CUGBP Elav-like family member 2 isoform X20

    7. XM_063276290.1 → XP_063132360.1  CUGBP Elav-like family member 2 isoform X1

    8. XM_063276289.1 → XP_063132359.1  CUGBP Elav-like family member 2 isoform X1

    9. XM_063276292.1 → XP_063132362.1  CUGBP Elav-like family member 2 isoform X3

    10. XM_039095585.2 → XP_038951513.2  CUGBP Elav-like family member 2 isoform X6

    11. XM_063276293.1 → XP_063132363.1  CUGBP Elav-like family member 2 isoform X4

    12. XM_063276294.1 → XP_063132364.1  CUGBP Elav-like family member 2 isoform X4

    13. XM_063276291.1 → XP_063132361.1  CUGBP Elav-like family member 2 isoform X2

      Related
      ENSRNOP00000093103.1, ENSRNOT00000113911.2

    14. XM_063276295.1 → XP_063132365.1  CUGBP Elav-like family member 2 isoform X5

    15. XM_063276296.1 → XP_063132366.1  CUGBP Elav-like family member 2 isoform X5

    16. XM_063276297.1 → XP_063132367.1  CUGBP Elav-like family member 2 isoform X5

      Related
      ENSRNOP00000104906.1, ENSRNOT00000162110.1

    17. XM_063276298.1 → XP_063132368.1  CUGBP Elav-like family member 2 isoform X7

    18. XM_008771863.4 → XP_008770085.2  CUGBP Elav-like family member 2 isoform X10

    19. XM_063276299.1 → XP_063132369.1  CUGBP Elav-like family member 2 isoform X8

    20. XM_063276300.1 → XP_063132370.1  CUGBP Elav-like family member 2 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZWV8
      Related
      ENSRNOP00000083368.1, ENSRNOT00000097332.2

    21. XM_039095591.2 → XP_038951519.1  CUGBP Elav-like family member 2 isoform X19

      Conserved Domains (3) summary
      cd12638
      Location:438 → 529
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:51 → 134
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:143 → 223
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    22. XM_063276310.1 → XP_063132380.1  CUGBP Elav-like family member 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6G2N0

    23. XM_063276311.1 → XP_063132381.1  CUGBP Elav-like family member 2 isoform X22

      UniProtKB/TrEMBL
      A0A8I6G2N0
      Related
      ENSRNOP00000095071.2, ENSRNOT00000093949.2

    24. XM_063276309.1 → XP_063132379.1  CUGBP Elav-like family member 2 isoform X21

    25. XM_063276314.1 → XP_063132384.1  CUGBP Elav-like family member 2 isoform X24

    26. XM_063276315.1 → XP_063132385.1  CUGBP Elav-like family member 2 isoform X24

      Related
      ENSRNOP00000078975.2, ENSRNOT00000113172.2

    27. XM_063276324.1 → XP_063132394.1  CUGBP Elav-like family member 2 isoform X33

      UniProtKB/TrEMBL
      A0A8I6GLG1

    28. XM_063276318.1 → XP_063132388.1  CUGBP Elav-like family member 2 isoform X26

    29. XM_063276306.1 → XP_063132376.1  CUGBP Elav-like family member 2 isoform X18

    30. XM_063276322.1 → XP_063132392.1  CUGBP Elav-like family member 2 isoform X30

    31. XM_063276303.1 → XP_063132373.1  CUGBP Elav-like family member 2 isoform X16

    32. XM_063276321.1 → XP_063132391.1  CUGBP Elav-like family member 2 isoform X29

    33. XM_063276327.1 → XP_063132397.1  CUGBP Elav-like family member 2 isoform X29

    34. XM_063276320.1 → XP_063132390.1  CUGBP Elav-like family member 2 isoform X28

      UniProtKB/TrEMBL
      A6JLW4

    35. XM_039095604.2 → XP_038951532.1  CUGBP Elav-like family member 2 isoform X31

      UniProtKB/Swiss-Prot
      A1L1J5, O88756, Q78ZF0, Q792H5
      UniProtKB/TrEMBL
      A0A8I5ZJI1
      Related
      ENSRNOP00000084524.2, ENSRNOT00000101298.2
      Conserved Domains (4) summary
      TIGR01661
      Location:60 → 473
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12631
      Location:57 → 140
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:149 → 229
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cl17169
      Location:437 → 477
      RRM_SF; RNA recognition motif (RRM) superfamily

    36. XM_039095586.2 → XP_038951514.1  CUGBP Elav-like family member 2 isoform X9

      Conserved Domains (3) summary
      cd12638
      Location:454 → 545
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:67 → 150
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:159 → 239
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    37. XM_008771862.4 → XP_008770084.2  CUGBP Elav-like family member 2 isoform X11

      Related
      ENSRNOP00000023436.6, ENSRNOT00000023436.6

    38. XM_039095584.2 → XP_038951512.2  CUGBP Elav-like family member 2 isoform X14

    39. XM_008771864.4 → XP_008770086.2  CUGBP Elav-like family member 2 isoform X14

    40. XM_063276316.1 → XP_063132386.1  CUGBP Elav-like family member 2 isoform X25

    41. XM_063276317.1 → XP_063132387.1  CUGBP Elav-like family member 2 isoform X25

      Related
      ENSRNOP00000084295.2, ENSRNOT00000095889.2

    42. XM_063276325.1 → XP_063132395.1  CUGBP Elav-like family member 2 isoform X34

    43. XM_039095594.2 → XP_038951522.1  CUGBP Elav-like family member 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZWW9, Z4YNP1
      Conserved Domains (3) summary
      cd12638
      Location:429 → 520
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    44. XM_063276313.1 → XP_063132383.1  CUGBP Elav-like family member 2 isoform X23

      UniProtKB/TrEMBL
      A0A8I5ZWW9

    45. XM_063276323.1 → XP_063132393.1  CUGBP Elav-like family member 2 isoform X32

    46. XM_039095595.2 → XP_038951523.1  CUGBP Elav-like family member 2 isoform X27

      UniProtKB/TrEMBL
      Z4YNP1
      Conserved Domains (3) summary
      cd12638
      Location:423 → 514
      RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
      cd12631
      Location:46 → 129
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12634
      Location:138 → 218
      RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

    47. XM_063276319.1 → XP_063132389.1  CUGBP Elav-like family member 2 isoform X27

    48. XM_063276326.1 → XP_063132396.1  CUGBP Elav-like family member 2 isoform X35

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q792H5.1 GenPept UniProtKB/Swiss-Prot:Q792H5

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