Uncx UNC homeobox [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uncxprovided by RGD
Official Full Name: UNC homeoboxprovided by RGD
Primary source: RGD:69361
See related: EnsemblRapid:ENSRNOG00000001284 AllianceGenome:RGD:69361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chx4; PHD1; Uncx4.1
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within several processes, including cartilage condensation; central nervous system development; and common myeloid progenitor cell proliferation. Predicted to be located in nucleus. Orthologous to human UNCX (UNC homeobox). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 9.7) and Kidney (RPKM 3.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20206604..20211125, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15092779..15097300, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17182158..17186679, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Uncx (e-PCR), detects polymorphism
- UniSTS:547385

Uncx4.1 (e-PCR), detects polymorphism
- UniSTS:144731

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cartilage condensation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cartilage condensation	ISO Inferred from Sequence Orthology more info
involved_in common myeloid progenitor cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within common myeloid progenitor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in dorsal spinal cord development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb interneuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within olfactory bulb interneuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein unc-4 homolog

Names: Unc4.1 homeobox; homeobox protein Uncx4.1; paired-type homeodomain transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017179.2 → NP_058875.2 homeobox protein unc-4 homolog

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P97830

UniProtKB/TrEMBL

A6K1V1, G3V653

Related

ENSRNOP00000001730.4, ENSRNOT00000001730.6

Conserved Domains (2) summary

PHA03247
Location:289 → 524

PHA03247; large tegument protein UL36; Provisional

pfam00046
Location:112 → 166

Homeobox; Homeobox domain