Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2c11provided by RGD
Official Full Name: cytochrome P450, subfamily 2, polypeptide 11provided by RGD
Primary source: RGD:2469
See related: EnsemblRapid:ENSRNOG00000052810 AllianceGenome:RGD:2469
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2c; CYP2CII; Cyp2c11l
Summary: Enables arachidonate 11,12-epoxygenase activity; arachidonate 14,15-epoxygenase activity; and testosterone 16-alpha-hydroxylase activity. Involved in epoxygenase P450 pathway and icosanoid biosynthetic process. Located in endoplasmic reticulum membrane. Biomarker of depressive disorder; end stage renal disease; and hypertension. Orthologous to human CYP2C18 (cytochrome P450 family 2 subfamily C member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2884.0) See more
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Genomic context

Location:: 1q53

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (246175216..246211445)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (236762719..236799069)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (257676172..258004428)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Title: Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain.
Inflammation in astrocytes could down-regulate CYP2C11 mRNA, protein and activity.Inhibition of NF-kappaB partially prevented the down-regulation of CYP2C11 mRNA and protein.NF-kappaB is able to bind to at least two response elements in the promoter of Cyp2c11.
Title: Role of NF-κB in cytochrome P450 epoxygenases down-regulation during an inflammatory process in astrocytes.
A CYP2C11-null rat model was successfully generated and is a valuable tool to study the in vivo function of CYP2C11.
Title: Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method.
Intragastric administration of suberoylanilide hydroxamic acid induced CYP2C19 activity.
Title: Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities.
significant changes in the activity of CYP2C19 under the special environment of acute high altitude hypoxia
Title: [Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19].
Data suggest that short-term fasting up-regulates hepatic expression of CYP1A2, CYP2C19, CYP2D6, and CYP3A4, but down-regulates hepatic expression of CYP2C9 as compared with the post-absorptive state.
Title: Short-term fasting alters cytochrome P450-mediated drug metabolism in humans.
acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways.
Title: The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
The PE extract also showed a significant potential to reduce CYP3A and CYP2C protein expression by approximately 50%.
Title: Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and CYP2C11) expression and pharmacokinetics of carbamazepine in rats.
CYP2C11 and CYP2C23 epoxygenases were highly expressed in interlobar renal arteries and renal cortex, respectively, and were co-localized with eNOS in renal endothelial cells. These results demonstrate that H2O2 is involved in the EDH-type relaxant responses of renal arteries and that CYP 2C epoxygenases are physiologically relevant endothelial sources of vasodilator H2O2 in the kidney.
Title: CYP epoxygenase-derived H(2)O(2) is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries.
Report effect of hemodialysis on hepatic cytochrome CYP2c11 functional expression.
Title: Effect of hemodialysis on hepatic cytochrome P450 functional expression.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Markers

RH94623 (e-PCR)
- UniSTS:119871

D1Wox47 (e-PCR)
- UniSTS:519033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate 11,12-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate 14,15-epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 16-alpha-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables testosterone 16-alpha-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2C11

Names: CYPIIC11; P-450(M-1); P450-UT-A; P450H; UT-2; cytochrome P-450(M-1); cytochrome P450 2C11-like; cytochrome P450, 2c29; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 11; cytochrome P450-UT-2; cytochrome P450-UT-A; cytochrome P450H

NP_062057.2

EC 1.14.14.1

XP_008758586.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019184.2 → NP_062057.2 cytochrome P450 2C11

See identical proteins and their annotated locations for NP_062057.2

Status: PROVISIONAL

Source sequence(s)

J02657

UniProtKB/Swiss-Prot

P08683, Q63141, Q64554

UniProtKB/TrEMBL

A0A0G2K879, A6I196

Related

ENSRNOP00000098982.1, ENSRNOT00000132305.1

Conserved Domains (1) summary

pfam00067
Location:30 → 487

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

246175216..246211445

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760364.4 → XP_008758586.2 cytochrome P450 2C11 isoform X1

UniProtKB/TrEMBL

A0A0G2K879

Related

ENSRNOP00000101757.1, ENSRNOT00000140439.1

Conserved Domains (1) summary

cd20665
Location:15 → 438

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s