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    Dpp6 dipeptidyl peptidase like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29272, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dpp6provided by RGD
    Official Full Name
    dipeptidyl peptidase like 6provided by RGD
    Primary source
    RGD:68402
    See related
    EnsemblRapid:ENSRNOG00000030547 AllianceGenome:RGD:68402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DPP VI
    Summary
    Predicted to enable potassium channel regulator activity. Involved in positive regulation of potassium ion transport and positive regulation of protein localization to plasma membrane. Located in cell surface and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 198.4) and Adrenal (RPKM 21.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpp6 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (8323220..9242694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (7589386..8508666, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (4021021..4943675, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene transfer RNA valine (anticodon AAC) 11 Neighboring gene uncharacterized LOC134486537 Neighboring gene PAX interacting protein 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 89 Neighboring gene uncharacterized LOC120102469 Neighboring gene 60S ribosomal protein L10a pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 4, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients. Del Bo R, et al. J Neurol Neurosurg Psychiatry, 2008 Sep. PMID 18708572
    2. Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells. Jerng HH, et al. PLoS One, 2012. PMID 22675523, Free PMC Article
    3. Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. Kin Y, et al. J Biochem, 2001 Feb. PMID 11173531
    4. Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients. Li XG, et al. Chin Med J (Engl), 2009 Dec 20. PMID 20137488
    5. Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation. Alders M, et al. Am J Hum Genet, 2009 Apr. PMID 19285295, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.
      Title: DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.
    2. The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
      Title: Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
    3. a novel component of A-type K(+) channels
      Title: The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables dipeptidyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-type potassium channel modulatory protein DPP6; dipeptidyl aminopeptidase-like protein 6
    Names
    DPPX
    dipeptidyl aminopeptidase-related protein
    dipeptidyl peptidase IV-like protein
    dipeptidyl peptidase VI
    dipeptidylpeptidase 6
    dipeptidylpeptidase VI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022850.2 → NP_074041.2  A-type potassium channel modulatory protein DPP6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P46101
      UniProtKB/TrEMBL
      A0A8I6A0E2
      Related
      ENSRNOP00000084952.1, ENSRNOT00000108476.2
      Conserved Domains (2) summary
      pfam00930
      Location:189 → 555
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:635 → 844
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      8323220..9242694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592501.3 → XP_017447990.1  dipeptidyl aminopeptidase-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQR2, A6KJK3
      Related
      ENSRNOP00000080650.1, ENSRNOT00000117212.2
      Conserved Domains (2) summary
      pfam00930
      Location:134 → 500
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:580 → 789
      Abhydrolase; alpha/beta hydrolases

    2. XM_017592503.3 → XP_017447992.1  dipeptidyl aminopeptidase-like protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR04, A6KJK3
      Related
      ENSRNOP00000080741.1, ENSRNOT00000093848.2
      Conserved Domains (2) summary
      pfam00930
      Location:131 → 497
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:577 → 786
      Abhydrolase; alpha/beta hydrolases

    3. XM_017592504.3 → XP_017447993.1  dipeptidyl aminopeptidase-like protein 6 isoform X4

      UniProtKB/TrEMBL
      A6KJK3

    4. XM_006235880.5 → XP_006235942.1  dipeptidyl aminopeptidase-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A6KJK3, F1LMR7
      Related
      ENSRNOP00000043113.2, ENSRNOT00000045773.4
      Conserved Domains (2) summary
      pfam00930
      Location:133 → 499
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:579 → 788
      Abhydrolase; alpha/beta hydrolases

    5. XM_063285681.1 → XP_063141751.1  dipeptidyl aminopeptidase-like protein 6 isoform X5

    6. XM_063285682.1 → XP_063141752.1  dipeptidyl aminopeptidase-like protein 6 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46101.1 GenPept UniProtKB/Swiss-Prot:P46101

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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