Tnks tankyrase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnksprovided by RGD
Official Full Name: tankyraseprovided by RGD
Primary source: RGD:1308784
See related: EnsemblRapid:ENSRNOG00000011625 AllianceGenome:RGD:1308784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; histone binding activity; and zinc ion binding activity. Involved in cellular response to nutrient. Predicted to be located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 111.8), Lung (RPKM 104.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.2

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (63922969..64073972)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (57223174..57370740)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (60925093..61067192)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied role of tankyrase and effect of tankyrase inhibitor XAV939 on corpus luteum development , luteal function, and Wnt/beta-catenin signaling in gonadotropin-treated prepubertal rats.
Title: Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats.
tankyrase-mediated PARsylation is promoted by nutritional energy stimulated NAD+ in insulinoma cells
Title: Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells.
Tankyrase 1 and autophagy decrease in the corpus cavernosum smooth muscle cells from aging rats with erectile dysfunction, and tankyrase 1 may have a positive effect on proliferation by enhancing autophagy and regulating the mTOR signalling pathway.
Title: Effect of tankyrase 1 on autophagy in the corpus cavernosum smooth muscle cells from ageing rats with erectile dysfunction and its potential mechanism.
Increased STAT-1, IRF-1 and complement component C3 in several models of liver transplant tolerance suggests that the STAT-1/IRF-1 apoptotic pathway and C3 may be involved in the tolerogenic mechanism.
Title: Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction.

Submit: New GeneRIF Correction

General gene information

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Markers

BI289331 (e-PCR)
- UniSTS:246784

BE111758 (e-PCR)
- UniSTS:245770

RH143994 (e-PCR)
- UniSTS:233240

RH142999 (e-PCR)
- UniSTS:232246

RH129333 (e-PCR)
- UniSTS:212640

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomere lengthening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase tankyrase-1

Names: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1

NP_001099554.2

EC 2.4.2.30

XP_038950318.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106084.2 → NP_001099554.2 poly [ADP-ribose] polymerase tankyrase-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I5YBL7, D3Z8Q6

Related

ENSRNOP00000015813.6, ENSRNOT00000015813.8

Conserved Domains (8) summary

cd09524
Location:1014 → 1079

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

smart00454
Location:1020 → 1077

SAM; Sterile alpha motif

cd00204
Location:666 → 791

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01438
Location:1081 → 1303

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

pfam00644
Location:1095 → 1298

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12796
Location:678 → 770

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:793 → 847

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:361 → 389

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

63922969..64073972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094390.2 → XP_038950318.1 poly [ADP-ribose] polymerase tankyrase-1 isoform X1

UniProtKB/TrEMBL

A0A8I5YBL7

Conserved Domains (5) summary

PHA02876
Location:2 → 379

PHA02876; ankyrin repeat protein; Provisional

cd09524
Location:787 → 852

SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily

PHA03095
Location:415 → 739

PHA03095; ankyrin-like protein; Provisional

cd01438
Location:854 → 1076

tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...

sd00045
Location:134 → 162

ANK; ANK repeat [structural motif]