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    Pex19 peroxisomal biogenesis factor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289233, updated on 2-Nov-2024

    Summary

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    Symbol
    Pex19provided by RGD
    Full Name
    peroxisomal biogenesis factor 19provided by RGD
    Primary source
    RGD:1306913
    See related
    EnsemblRapid:ENSRNOG00000057116 AllianceGenome:RGD:1306913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PxF
    Summary
    Predicted to enable ATPase binding activity; peroxisome membrane class-1 targeting sequence binding activity; and protein carrier chaperone. Predicted to be involved in chaperone-mediated protein folding; peroxisome organization; and protein stabilization. Located in brush border membrane and peroxisome. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 12A. Orthologous to human PEX19 (peroxisomal biogenesis factor 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 221.4), Adrenal (RPKM 202.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pex19 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (87124654..87141170)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84592277..84608793)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90514324..90530825)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nicastrin Neighboring gene COPI coat complex subunit alpha Neighboring gene DDB1 and CUL4 associated factor 8 Neighboring gene proliferation and apoptosis adaptor protein 15 Neighboring gene calsequestrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Peroxisome biogenesis: a novel inducible PEX19 splicing variant is involved in early stages of peroxisome proliferation. Kinoshita N, et al. J Biochem, 2017 Mar 1. PMID 28391327
    2. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein. Kammerer S, et al. Genomics, 1997 Oct 1. PMID 9339377
    3. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Matsuzono Y, et al. Proc Natl Acad Sci U S A, 1999 Mar 2. PMID 10051604, Free PMC Article
    4. Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate. Ito M, et al. Biochem J, 2004 Feb 1. PMID 14558883, Free PMC Article
    5. Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. Halbach A, et al. J Cell Sci, 2006 Jun 15. PMID 16763195

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome membrane class-1 targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome membrane targeting sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein carrier chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal biogenesis factor 19
    Names
    peroxin-19
    peroxisomal farnesylated protein
    peroxisome biogenesis factor 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107375.2 → NP_001100845.1  peroxisomal biogenesis factor 19 isoform 1

      See identical proteins and their annotated locations for NP_001100845.1

      Status: VALIDATED

      Source sequence(s)
      AI712677, BF543157, CB718412, CK600534, CK838542, CO573662
      UniProtKB/Swiss-Prot
      Q9QYU1
      UniProtKB/TrEMBL
      A6JG25
      Related
      ENSRNOP00000086472.2, ENSRNOT00000101318.2
      Conserved Domains (1) summary
      pfam04614
      Location:74 → 299
      Pex19; Pex19 protein family

    2. NM_001134777.1 → NP_001128249.1  peroxisomal biogenesis factor 19 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BE108398, BQ782704, CB718412, CK600534
      UniProtKB/TrEMBL
      A6JG28
      Related
      ENSRNOP00000072373.3, ENSRNOT00000088996.3
      Conserved Domains (1) summary
      pfam04614
      Location:74 → 272
      Pex19; Pex19 protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      87124654..87141170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090518.1 → XP_038946446.1  peroxisomal biogenesis factor 19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2A5
      Conserved Domains (1) summary
      pfam04614
      Location:91 → 290
      Pex19; Pex19 protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYU1.1 GenPept UniProtKB/Swiss-Prot:Q9QYU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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