Cacybp calcyclin binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacybpprovided by RGD
Official Full Name: calcyclin binding proteinprovided by RGD
Primary source: RGD:1303146
See related: AllianceGenome:RGD:1303146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to calcium ion; positive regulation of DNA replication; and response to growth hormone. Located in several cellular components, including cell body; neuron projection; and nucleus. Biomarker of myocardial infarction. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 412.4), Brain (RPKM 390.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (74970917..74981298, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (72437485..72447810, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (77948771..77959089, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of the Expression and Localization of the Multifunctional Protein CacyBP/SIP and Elements of the MAPK Signaling Pathway in the Adrenal Glands of Rats with Primary and Secondary Hypertension.
Title: Evaluation of the Expression and Localization of the Multifunctional Protein CacyBP/SIP and Elements of the MAPK Signaling Pathway in the Adrenal Glands of Rats with Primary and Secondary Hypertension.
Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension.
Title: Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension.
CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
Title: CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
The level of CacyBP/SIP increases during development of breast cancer.
Title: Up-regulation of CacyBP/SIP during rat breast cancer development.
Thus, our results show that localization of CacyBP/SIP in brain neurons is similar to that observed for tau and tubulin, which points to the involvement of CacyBP/SIP in cytoskeletal physiology.
Title: Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein.
CacyBP/SIP may play a role in cardiomyogenic differentiation and possibly protection of cardiomyocytes during hypoxia/reoxygenation injury.
Title: Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiac muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in response to growth hormone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcyclin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004208.1 → NP_001004208.1 calcyclin-binding protein

See identical proteins and their annotated locations for NP_001004208.1

Status: PROVISIONAL

Source sequence(s)

BC079007

UniProtKB/Swiss-Prot

Q6AYK6

UniProtKB/TrEMBL

A0A096MJT0, A6ID58

Conserved Domains (3) summary

cd06468
Location:76 → 168

p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...

pfam05002
Location:183 → 218

SGS; SGS domain

pfam09032
Location:5 → 76

Siah-Interact_N; Siah interacting protein, N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

74970917..74981298 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598707.2 → XP_017454196.1 calcyclin-binding protein isoform X1

UniProtKB/TrEMBL

A0A096MJT0, A6ID59

Conserved Domains (3) summary

cd06468
Location:31 → 123

p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...

pfam05002
Location:138 → 173

SGS; SGS domain

pfam09032
Location:1 → 31

Siah-Interact_N; Siah interacting protein, N terminal