Mri1 methylthioribose-1-phosphate isomerase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mri1provided by RGD
Official Full Name: methylthioribose-1-phosphate isomerase 1provided by RGD
Primary source: RGD:1307789
See related: EnsemblRapid:ENSRNOG00000026211 AllianceGenome:RGD:1307789
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307789
Summary: Predicted to enable S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 107.0), Adrenal (RPKM 98.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40812114..40819846)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23907327..23913721)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25360299..25366283, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-methyl-5-thioribose-1-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methylthioribose-1-phosphate isomerase

Names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; methylthioribose-1-phosphate isomerase homolog; translation initiation factor eIF-2B subunit alpha/beta/delta-like protein

NP_001010947.1

EC 5.3.1.23

XP_063133899.1

EC 5.3.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010947.2 → NP_001010947.1 methylthioribose-1-phosphate isomerase

See identical proteins and their annotated locations for NP_001010947.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q5HZE4

UniProtKB/TrEMBL

A6IY99

Related

ENSRNOP00000003762.4, ENSRNOT00000003762.8

Conserved Domains (2) summary

TIGR00512
Location:4 → 346

salvage_mtnA; S-methyl-5-thioribose-1-phosphate isomerase

pfam01008
Location:44 → 346

IF-2B; Initiation factor 2 subunit family