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    N4bp2l2 NEDD4 binding protein 2-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288416, updated on 2-Nov-2024

    Summary

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    Symbol
    N4bp2l2provided by RGD
    Full Name
    NEDD4 binding protein 2-like 2provided by RGD
    Primary source
    RGD:1359603
    See related
    EnsemblRapid:ENSRNOG00000001108 AllianceGenome:RGD:1359603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of hematopoietic stem cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of hematopoietic stem cell proliferation. Predicted to act upstream of or within blastocyst development. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 267.5), Spleen (RPKM 208.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See N4bp2l2 in Genome Data Viewer
    Location:
    12p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (4972967..5038027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (137342..200292, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (627128..650604, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene BRCA2, DNA repair associated Neighboring gene NEDD4 binding protein 2-like 1 Neighboring gene PDS5 cohesin associated factor B Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94223

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-binding protein 2-like 2
    Names
    phosphonoformate immuno-associated protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005533.2 → NP_001005533.1  NEDD4-binding protein 2-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001005533.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q66H65
      UniProtKB/TrEMBL
      A0A8I5ZLI8
      Related
      ENSRNOP00000078717.2, ENSRNOT00000116179.2
      Conserved Domains (1) summary
      pfam13671
      Location:395 → 528
      AAA_33; AAA domain

    2. NM_001400958.1 → NP_001387887.1  NEDD4-binding protein 2-like 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOP00000081414.2, ENSRNOT00000111844.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      4972967..5038027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271111.1 → XP_063127181.1  NEDD4-binding protein 2-like 2 isoform X3

      Related
      ENSRNOP00000088209.2, ENSRNOT00000118063.2

    2. XM_063271110.1 → XP_063127180.1  NEDD4-binding protein 2-like 2 isoform X2

    3. XM_039089151.2 → XP_038945079.1  NEDD4-binding protein 2-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIC7
      Conserved Domains (1) summary
      pfam13671
      Location:469 → 602
      AAA_33; AAA domain

    4. XM_063271114.1 → XP_063127184.1  NEDD4-binding protein 2-like 2 isoform X8

    5. XM_006248735.4 → XP_006248797.2  NEDD4-binding protein 2-like 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSH6
      Conserved Domains (1) summary
      pfam13671
      Location:469 → 602
      AAA_33; AAA domain

    6. XM_063271113.1 → XP_063127183.1  NEDD4-binding protein 2-like 2 isoform X6

    7. XM_063271112.1 → XP_063127182.1  NEDD4-binding protein 2-like 2 isoform X6

    8. XM_039089150.2 → XP_038945078.1  NEDD4-binding protein 2-like 2 isoform X5

      UniProtKB/TrEMBL
      A6KSV3
      Conserved Domains (1) summary
      pfam13671
      Location:469 → 556
      AAA_33; AAA domain

    9. XM_039089152.2 → XP_038945080.2  NEDD4-binding protein 2-like 2 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H65.1 GenPept UniProtKB/Swiss-Prot:Q66H65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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