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    Unc13c unc-13 homolog C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286931, updated on 2-Nov-2024

    Summary

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    Symbol
    Unc13cprovided by RGD
    Full Name
    unc-13 homolog Cprovided by RGD
    Primary source
    RGD:628592
    See related
    EnsemblRapid:ENSRNOG00000056612 AllianceGenome:RGD:628592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc13h3
    Summary
    Enables calmodulin binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle priming. Located in synaptic vesicle membrane. Orthologous to human UNC13C (unc-13 homolog C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 140.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc13c in Genome Data Viewer
    Location:
    8q24
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (83127650..83553822, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (74247026..74697629, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (80202736..80656363, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480206 Neighboring gene uncharacterized LOC134480073 Neighboring gene uncharacterized LOC102554551 Neighboring gene 60S ribosomal protein L27-like Neighboring gene WD repeat domain 72 Neighboring gene uncharacterized LOC120094209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. Augustin I, et al. J Neurosci, 2001 Jan 1. PMID 11150314, Free PMC Article
    2. Differential expression of two novel Munc13 proteins in rat brain. Augustin I, et al. Biochem J, 1999 Feb 1. PMID 9895278, Free PMC Article
    3. Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. Brose N, et al. J Biol Chem, 1995 Oct 20. PMID 7559667
    4. Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Lipstein N, et al. Mol Cell Biol, 2012 Nov. PMID 22966208, Free PMC Article
    5. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. Chen Z, et al. J Neurosci, 2013 May 8. PMID 23658173, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacylglycerol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin-1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dense core granule priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic dense core vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in calyx of Held IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-13 homolog C
    Names
    Munc13-3
    protein unc-13 homolog C-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173146.2 → NP_775169.4  protein unc-13 homolog C

      See identical proteins and their annotated locations for NP_775169.4

      Status: VALIDATED

      Source sequence(s)
      U75361
      UniProtKB/Swiss-Prot
      Q62770
      UniProtKB/TrEMBL
      A0A0G2K3J2
      Related
      ENSRNOP00000075433.2, ENSRNOT00000080662.3
      Conserved Domains (5) summary
      cd04027
      Location:1210 → 1336
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:2052 → 2171
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:1088 → 1137
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:1530 → 1636
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:1878 → 2014
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      83127650..83553822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264996.1 → XP_063121066.1  protein unc-13 homolog C isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62770.3 GenPept UniProtKB/Swiss-Prot:Q62770

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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