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    ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 286806, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ADAMTS4provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 4provided by VGNC
    Primary source
    VGNC:VGNC:25627
    See related
    Ensembl:ENSBTAG00000013210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ADAMTS4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (8303802..8311858)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene Fc epsilon receptor Ig Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene protoporphyrinogen oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of ADAMTS4 and ADAMTS5 in longissimus dorsi muscle related to meat tenderness in Nanyang cattle. Zhang XH, et al. Genet Mol Res, 2013 Oct 18. PMID 24222240
    2. Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. Tortorella MD, et al. J Biol Chem, 2009 Sep 4. PMID 19586907, Free PMC Article
    3. n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. Curtis CL, et al. J Biol Chem, 2000 Jan 14. PMID 10625599
    4. Expression of ADAMTS homologues in articular cartilage. Flannery CR, et al. Biochem Biophys Res Commun, 1999 Jul 5. PMID 10403768
    5. Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro. Voigt H, et al. Arthritis Res Ther, 2009. PMID 19778432, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAMTS4 participates in the regulation of muscle development in cattle.
      Title: Expression of ADAMTS4 and ADAMTS5 in longissimus dorsi muscle related to meat tenderness in Nanyang cattle.
    2. aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
      Title: Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.
    3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5
      Title: Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
    4. ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin
      Title: Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 4
    Names
    ADAM-TS 4
    ADAM-TS4
    ADAMTS-4
    ADMP-1
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
    aggrecanase-1
    NP_858053.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181667.1 → NP_858053.1  A disintegrin and metalloproteinase with thrombospondin motifs 4 precursor

      See identical proteins and their annotated locations for NP_858053.1

      Status: PROVISIONAL

      Source sequence(s)
      AF516915
      UniProtKB/Swiss-Prot
      A6QLR5, Q7YS95, Q9TT93
      Related
      ENSBTAP00000017583.5, ENSBTAT00000017583.6
      Conserved Domains (6) summary
      smart00209
      Location:531 → 575
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:218 → 425
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:218 → 428
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:78 → 181
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:687 → 803
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:438 → 509
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      8303802..8311858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TT93.3 GenPept UniProtKB/Swiss-Prot:Q9TT93

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials