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    ASPH aspartate beta-hydroxylase [ Bos taurus (cattle) ]

    Gene ID: 286771, updated on 6-Jun-2024

    Summary

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    Official Symbol
    ASPHprovided by VGNC
    Official Full Name
    aspartate beta-hydroxylaseprovided by VGNC
    Primary source
    VGNC:VGNC:26219
    See related
    BGD:BT20012; Ensembl:ENSBTAG00000026283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ASPH in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (27013601..27203439, complement)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene spindle and kinetochore-associated protein 3-like Neighboring gene U6 spliceosomal RNA Neighboring gene clavesin 1 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene sodium/potassium transporting ATPase interacting 3 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine liver aspartyl beta-hydroxylase. Purification and characterization. Wang QP, et al. J Biol Chem, 1991 Jul 25. PMID 1856229
    2. cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase. Jia S, et al. J Biol Chem, 1992 Jul 15. PMID 1378441
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137539

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptidyl-aspartic acid 3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-aspartic acid hydroxylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartyl/asparaginyl beta-hydroxylase
    Names
    ASP beta-hydroxylase
    peptide-aspartate beta-dioxygenase
    NP_777182.1
    XP_015329930.2
    XP_015329931.1
    XP_015329932.2
    XP_015329933.2
    XP_015329934.1
    XP_015329935.2
    XP_015329936.1
    XP_015329937.2
    XP_015329938.1
    XP_015329939.1
    XP_015329941.1
    XP_015329942.1
    XP_015329943.1
    XP_024857187.1
    XP_024857188.1
    XP_024857189.1
    XP_024857190.1
    XP_024857191.1
    XP_024857192.1
    XP_024857193.1
    XP_024857194.1
    XP_059749115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174757.2 → NP_777182.1  aspartyl/asparaginyl beta-hydroxylase

      See identical proteins and their annotated locations for NP_777182.1

      Status: PROVISIONAL

      Source sequence(s)
      M91213
      UniProtKB/Swiss-Prot
      Q28056
      Related
      ENSBTAP00000021267.3, ENSBTAT00000021267.4
      Conserved Domains (4) summary
      TIGR02795
      Location:338 → 451
      tol_pal_ybgF; tol-pal system protein YbgF
      pfam05279
      Location:46 → 306
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:454 → 478
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:587 → 740
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27013601..27203439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025001422.2 → XP_024857190.1  aspartyl/asparaginyl beta-hydroxylase isoform X13

      Conserved Domains (4) summary
      pfam05279
      Location:46 → 291
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:439 → 463
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:572 → 725
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26002
      Location:322 → 508
      TPR_11; TPR repeat

    2. XM_025001421.2 → XP_024857189.1  aspartyl/asparaginyl beta-hydroxylase isoform X12

      UniProtKB/TrEMBL
      A0AAA9TMU8
      Related
      ENSBTAP00000098564.1, ENSBTAT00000133347.1
      Conserved Domains (4) summary
      pfam05279
      Location:46 → 304
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:452 → 476
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:585 → 738
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26002
      Location:335 → 521
      TPR_11; TPR repeat

    3. XM_015474449.3 → XP_015329935.2  aspartyl/asparaginyl beta-hydroxylase isoform X8

      Conserved Domains (5) summary
      pfam05279
      Location:46 → 334
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:482 → 506
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:615 → 768
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:366 → 479
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:389 → 575
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    4. XM_025001420.2 → XP_024857188.1  aspartyl/asparaginyl beta-hydroxylase isoform X10

      UniProtKB/TrEMBL
      A0AAA9RSP8
      Related
      ENSBTAP00000075701.1, ENSBTAT00000103251.1
      Conserved Domains (5) summary
      pfam05279
      Location:46 → 319
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:467 → 491
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:600 → 753
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:351 → 464
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:374 → 560
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    5. XM_025001419.2 → XP_024857187.1  aspartyl/asparaginyl beta-hydroxylase isoform X5

      Conserved Domains (5) summary
      pfam05279
      Location:46 → 349
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:497 → 521
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:630 → 783
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:381 → 494
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:404 → 590
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    6. XM_015474445.2 → XP_015329931.1  aspartyl/asparaginyl beta-hydroxylase isoform X2

      Conserved Domains (4) summary
      TIGR02795
      Location:410 → 523
      tol_pal_ybgF; tol-pal system protein YbgF
      pfam05279
      Location:88 → 378
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:526 → 550
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:659 → 812
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase

    7. XM_015474444.3 → XP_015329930.2  aspartyl/asparaginyl beta-hydroxylase isoform X1

      Conserved Domains (5) summary
      pfam05279
      Location:88 → 391
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:539 → 563
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:672 → 825
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:423 → 536
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:446 → 632
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    8. XM_015474446.3 → XP_015329932.2  aspartyl/asparaginyl beta-hydroxylase isoform X3

      Conserved Domains (4) summary
      pfam05279
      Location:88 → 376
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:524 → 548
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:657 → 810
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26002
      Location:407 → 593
      TPR_11; TPR repeat

    9. XM_015474448.2 → XP_015329934.1  aspartyl/asparaginyl beta-hydroxylase isoform X6

      Conserved Domains (5) summary
      pfam05279
      Location:88 → 348
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:496 → 520
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:629 → 782
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      pfam13428
      Location:383 → 422
      TPR_14; Tetratricopeptide repeat
      pfam13432
      Location:383 → 453
      TPR_16; Tetratricopeptide repeat

    10. XM_015474447.3 → XP_015329933.2  aspartyl/asparaginyl beta-hydroxylase isoform X4

      Conserved Domains (4) summary
      pfam05279
      Location:88 → 361
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:509 → 533
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:642 → 795
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26002
      Location:392 → 578
      TPR_11; TPR repeat

    11. XM_015474450.2 → XP_015329936.1  aspartyl/asparaginyl beta-hydroxylase isoform X9

      Conserved Domains (5) summary
      pfam05279
      Location:88 → 333
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:481 → 505
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:614 → 767
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      pfam13428
      Location:368 → 407
      TPR_14; Tetratricopeptide repeat
      pfam13432
      Location:368 → 438
      TPR_16; Tetratricopeptide repeat

    12. XM_059893132.1 → XP_059749115.1  aspartyl/asparaginyl beta-hydroxylase isoform X7

    13. XM_025001425.2 → XP_024857193.1  aspartyl/asparaginyl beta-hydroxylase isoform X16

      Conserved Domains (5) summary
      pfam05279
      Location:12 → 257
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:405 → 429
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:538 → 691
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:289 → 402
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:312 → 498
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    14. XM_025001424.2 → XP_024857192.1  aspartyl/asparaginyl beta-hydroxylase isoform X15

      UniProtKB/TrEMBL
      A0AAA9S198
      Related
      ENSBTAP00000078748.1, ENSBTAT00000096983.1
      Conserved Domains (5) summary
      pfam05279
      Location:12 → 270
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:418 → 442
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:551 → 704
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:302 → 415
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:325 → 511
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    15. XM_025001423.2 → XP_024857191.1  aspartyl/asparaginyl beta-hydroxylase isoform X14

      Conserved Domains (5) summary
      pfam05279
      Location:12 → 285
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:428 → 458
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:566 → 719
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:317 → 430
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:340 → 526
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    16. XM_015474451.3 → XP_015329937.2  aspartyl/asparaginyl beta-hydroxylase isoform X11

      Conserved Domains (5) summary
      pfam05279
      Location:12 → 315
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      sd00006
      Location:458 → 488
      TPR; TPR repeat [structural motif]
      pfam05118
      Location:596 → 749
      Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
      cl26250
      Location:347 → 460
      TPR_6; Tetratricopeptide repeat
      cl27017
      Location:370 → 556
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    17. XM_015474455.3 → XP_015329941.1  aspartyl/asparaginyl beta-hydroxylase isoform X19

      Related
      ENSBTAP00000069793.2, ENSBTAT00000085558.2
      Conserved Domains (1) summary
      pfam05279
      Location:46 → 245
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    18. XM_015474452.3 → XP_015329938.1  aspartyl/asparaginyl beta-hydroxylase isoform X17

      Conserved Domains (1) summary
      pfam05279
      Location:88 → 287
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    19. XM_015474453.3 → XP_015329939.1  aspartyl/asparaginyl beta-hydroxylase isoform X18

      Conserved Domains (1) summary
      pfam05279
      Location:88 → 272
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    20. XM_015474456.3 → XP_015329942.1  aspartyl/asparaginyl beta-hydroxylase isoform X21

      Conserved Domains (1) summary
      pfam05279
      Location:12 → 196
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    21. XM_025001426.2 → XP_024857194.1  aspartyl/asparaginyl beta-hydroxylase isoform X20

      Conserved Domains (1) summary
      pfam05279
      Location:12 → 211
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    22. XM_015474457.3 → XP_015329943.1  aspartyl/asparaginyl beta-hydroxylase isoform X22

      UniProtKB/TrEMBL
      Q29RR2
      Related
      ENSBTAP00000044438.2, ENSBTAT00000047216.4
      Conserved Domains (1) summary
      pfam05279
      Location:46 → 149
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

    RNA

    1. XR_003038026.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28056.1 GenPept UniProtKB/Swiss-Prot:Q28056

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