U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PARP1 poly(ADP-ribose) polymerase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 286764, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PARP1
    Gene description
    poly(ADP-ribose) polymerase 1
    See related
    BGD:BT27335; Ensembl:ENSBTAG00000000837
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADPRT; ARTD1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PARP1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (29365001..29406453, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene trithorax group protein osa Neighboring gene isopentenyl-diphosphate Delta-isomerase 1-like Neighboring gene uncharacterized LOC132342450 Neighboring gene stum, mechanosensory transduction mediator homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection. De Matteis G, et al. Cells, 2021 Mar 9. PMID 33803196, Free PMC Article
    2. Assessment of calpain and caspase systems activities during ageing of two bovine muscles by degradation patterns of αII spectrin and PARP-1. Saccà E, et al. Anim Sci J, 2016 Mar. PMID 26950517
    3. Depression in gene expression for poly(ADP-ribose) synthetase during the interferon-gamma-induced activation process of murine macrophage tumor cells. Taniguchi T, et al. Eur J Biochem, 1988 Feb 1. PMID 2450019
    4. Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions. Saito I, et al. Gene, 1990 Jun 15. PMID 2119324
    5. Lack of an association between two BER gene polymorphisms and breast cancer risk: a meta-analysis. Wu B, et al. PLoS One, 2012. PMID 23272074, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection.
      Title: New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection.
    2. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected
      Title: Assessment of calpain and caspase systems activities during ageing of two bovine muscles by degradation patterns of αII spectrin and PARP-1.
    3. ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk
      Title: Lack of an association between two BER gene polymorphisms and breast cancer risk: a meta-analysis.
    4. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
      Title: Poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites.
    5. FGF2 stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK)-dependent pathway
      Title: FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase)
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    DNA ADP-ribosyltransferase PARP1
    NAD(+) ADP-ribosyltransferase 1
    PARP-1
    poly (ADP-ribose) polymerase family, member 1
    poly(ADP-ribose) synthetase
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    protein poly-ADP-ribosyltransferase PARP1
    NP_777176.1
    XP_005216853.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174751.2 → NP_777176.1  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_777176.1

      Status: PROVISIONAL

      Source sequence(s)
      D90073
      UniProtKB/Swiss-Prot
      P18493, Q9TS00
      UniProtKB/TrEMBL
      A0A3Q1MVZ1
      Related
      ENSBTAP00000059409.1, ENSBTAT00000080992.2
      Conserved Domains (6) summary
      cd08001
      Location:545 → 647
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:6 → 1012
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:664 → 1008
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:387 → 463
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:12 → 87
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:283 → 334
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      29365001..29406453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216796.5 → XP_005216853.1  poly [ADP-ribose] polymerase 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MVZ1
      Related
      ENSBTAP00000001113.5, ENSBTAT00000001113.6
      Conserved Domains (6) summary
      cd08001
      Location:542 → 644
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:6 → 1009
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:661 → 1005
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:384 → 460
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:12 → 87
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:280 → 331
      PADR1; PADR1 (NUC008) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18493.2 GenPept UniProtKB/Swiss-Prot:P18493

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials