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    DYNAP dynactin associated protein [ Homo sapiens (human) ]

    Gene ID: 284254, updated on 2-Nov-2024

    Summary

    Official Symbol
    DYNAPprovided by HGNC
    Official Full Name
    dynactin associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26808
    See related
    Ensembl:ENSG00000178690 MIM:619421; AllianceGenome:HGNC:26808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C18orf26
    Summary
    Involved in several processes, including activation of protein kinase B activity; cellular response to ergosterol; and positive regulation of cell population proliferation. Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward esophagus (RPKM 7.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DYNAP in Genome Data Viewer
    Location:
    18q21.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (54575621..54599493)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (54778729..54802601)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52254990..52266724)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr18:52054867-52055490, GRCh37_chr18:52055491-52056114 and GRCh37_chr18:52056115-52056737 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:52056738-52057362 Neighboring gene DYNAP pseudogene 1 Neighboring gene DYNAP pseudogene 2 Neighboring gene DYNAP pseuodgene 3 Neighboring gene uncharacterized LOC124904308 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:52274507-52275298 Neighboring gene Sharpr-MPRA regulatory region 14135 Neighboring gene Sharpr-MPRA regulatory region 5858 Neighboring gene RAB27B, member RAS oncogene family Neighboring gene ribosomal protein SA pseudogene 57

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General protein information

    Preferred Names
    dynactin-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307955.1NP_001294884.1  dynactin-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' structure, initiates translation from an alternate start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AC091135
      Consensus CDS
      CCDS77190.1
      UniProtKB/TrEMBL
      K7EMN5
      Related
      ENSP00000466577.1, ENST00000585973.1
      Conserved Domains (1) summary
      pfam15675
      Location:5685
      CLLAC; CLLAC-motif containing domain
    2. NM_173629.3NP_775900.2  dynactin-associated protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091135
      Consensus CDS
      CCDS11957.2
      UniProtKB/Swiss-Prot
      Q8N1N2
      UniProtKB/TrEMBL
      A0A3B3IRJ4
      Related
      ENSP00000496812.1, ENST00000648945.2
      Conserved Domains (1) summary
      pfam15675
      Location:82111
      CLLAC; CLLAC-motif containing domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      54575621..54599493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525923.4XP_011524225.1  dynactin-associated protein isoform X1

      See identical proteins and their annotated locations for XP_011524225.1

      UniProtKB/Swiss-Prot
      Q8N1N2
      Conserved Domains (1) summary
      pfam15675
      Location:111140
      CLLAC; CLLAC-motif containing domain
    2. XM_017025709.2XP_016881198.1  dynactin-associated protein isoform X2

      UniProtKB/TrEMBL
      K7EMN5
      Conserved Domains (1) summary
      pfam15675
      Location:5685
      CLLAC; CLLAC-motif containing domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      54778729..54802601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318534.1XP_054174509.1  dynactin-associated protein isoform X1

    2. XM_054318536.1XP_054174511.1  dynactin-associated protein isoform X2

      UniProtKB/TrEMBL
      K7EMN5
    3. XM_054318535.1XP_054174510.1  dynactin-associated protein isoform X3