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    FUOM fucose mutarotase [ Homo sapiens (human) ]

    Gene ID: 282969, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FUOMprovided by HGNC
    Official Full Name
    fucose mutarotaseprovided by HGNC
    Primary source
    HGNC:HGNC:24733
    See related
    Ensembl:ENSG00000148803 MIM:617725; AllianceGenome:HGNC:24733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FUCU; FucM; C10orf125
    Summary
    Predicted to enable L-fucose mutarotase activity and fucose binding activity. Predicted to be involved in fucose metabolic process and fucosylation. Predicted to act upstream of or within female mating behavior and negative regulation of neuron differentiation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in liver (RPKM 9.1), duodenum (RPKM 5.8) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FUOM in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133352773..133358019, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134310274..134313135, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135168662..135171523, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene proline rich acidic protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135169540-135170274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2976 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135172784-135172946 Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4248 Neighboring gene uncharacterized LOC124902563 Neighboring gene microRNA 3944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135191859-135192358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2978

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization and role of fucose mutarotase in mammalian cells. Park D, et al. Glycobiology, 2007 Sep. PMID 17602138
    2. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. Lee KH, et al. J Mol Biol, 2009 Aug 7. PMID 19524593
    3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article
    5. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. Kumar P, et al. J Proteome Res, 2017 Aug 4. PMID 28675297, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26016, MGC149258

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-fucose mutarotase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucose binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables racemase and epimerase activity, acting on carbohydrates and derivatives ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    fucose mutarotase
    Names
    protein fucU homolog
    NP_001091953.1
    NP_001288756.1
    NP_001288757.1
    NP_940874.2
    XP_011537972.1
    XP_011537973.1
    XP_011537974.1
    XP_011537975.1
    XP_011537976.1
    XP_011537977.1
    XP_047281057.1
    XP_047281058.1
    XP_047281059.1
    XP_047281060.1
    XP_047281061.1
    XP_054221594.1
    XP_054221595.1
    XP_054221596.1
    XP_054221597.1
    XP_054221598.1
    XP_054221599.1
    XP_054221600.1
    XP_054221601.1
    XP_054221602.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098483.3 → NP_001091953.1  fucose mutarotase isoform 1

      See identical proteins and their annotated locations for NP_001091953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI333356, HY163253
      Consensus CDS
      CCDS44499.1
      UniProtKB/Swiss-Prot
      A1L300, A2VDF0, Q5VWY2, Q5VWY3, Q6ZPD2
      UniProtKB/TrEMBL
      X6RK00
      Related
      ENSP00000278025.5, ENST00000278025.9
      Conserved Domains (1) summary
      cl00809
      Location:4 → 147
      RbsD_FucU; RbsD / FucU transport protein family

    2. NM_001301827.2 → NP_001288756.1  fucose mutarotase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AI333356, AK129527, BM009909
      UniProtKB/TrEMBL
      X6RK00
      Related
      ENSP00000413379.2, ENST00000447176.5
      Conserved Domains (1) summary
      cl00809
      Location:4 → 124
      RbsD_FucU; RbsD / FucU transport protein family

    3. NM_001301828.2 → NP_001288757.1  fucose mutarotase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AI333356, AK129527, BU849497
      Consensus CDS
      CCDS76364.1
      UniProtKB/TrEMBL
      X6R6T9, X6RK00
      Related
      ENST00000465384.5
      Conserved Domains (1) summary
      cl00809
      Location:3 → 102
      RbsD_FucU; RbsD / FucU transport protein family

    4. NM_198472.3 → NP_940874.2  fucose mutarotase isoform 2

      See identical proteins and their annotated locations for NP_940874.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK129527, BC129819, CN368132
      Consensus CDS
      CCDS7680.1
      UniProtKB/Swiss-Prot
      A2VDF0
      Related
      ENSP00000357540.5, ENST00000368552.8
      Conserved Domains (1) summary
      cl00809
      Location:4 → 133
      RbsD_FucU; RbsD / FucU transport protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      133352773..133358019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539675.3 → XP_011537977.1  fucose mutarotase isoform X11

      Related
      ENSP00000520888.1, ENST00000850601.1
      Conserved Domains (1) summary
      cl00809
      Location:4 → 133
      RbsD_FucU; RbsD / FucU transport protein family

    2. XM_011539673.3 → XP_011537975.1  fucose mutarotase isoform X10

      Conserved Domains (1) summary
      cl00809
      Location:4 → 144
      RbsD_FucU; RbsD / FucU transport protein family

    3. XM_011539671.3 → XP_011537973.1  fucose mutarotase isoform X2

      Conserved Domains (1) summary
      cl00809
      Location:4 → 158
      RbsD_FucU; RbsD / FucU transport protein family

    4. XM_011539672.3 → XP_011537974.1  fucose mutarotase isoform X3

      Conserved Domains (1) summary
      cl00809
      Location:4 → 158
      RbsD_FucU; RbsD / FucU transport protein family

    5. XM_011539670.3 → XP_011537972.1  fucose mutarotase isoform X1

      Conserved Domains (1) summary
      cl00809
      Location:4 → 169
      RbsD_FucU; RbsD / FucU transport protein family

    6. XM_011539674.3 → XP_011537976.1  fucose mutarotase isoform X4

      Conserved Domains (1) summary
      cl00809
      Location:4 → 144
      RbsD_FucU; RbsD / FucU transport protein family

    7. XM_047425105.1 → XP_047281061.1  fucose mutarotase isoform X9

      UniProtKB/TrEMBL
      X6R6T9
      Related
      ENSP00000357539.1, ENST00000368551.1

    8. XM_047425102.1 → XP_047281058.1  fucose mutarotase isoform X6

    9. XM_047425103.1 → XP_047281059.1  fucose mutarotase isoform X7

    10. XM_047425101.1 → XP_047281057.1  fucose mutarotase isoform X5

    11. XM_047425104.1 → XP_047281060.1  fucose mutarotase isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      134310274..134313135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365621.1 → XP_054221596.1  fucose mutarotase isoform X3

    2. XM_054365622.1 → XP_054221597.1  fucose mutarotase isoform X4

    3. XM_054365625.1 → XP_054221600.1  fucose mutarotase isoform X7

    4. XM_054365627.1 → XP_054221602.1  fucose mutarotase isoform X9

      UniProtKB/TrEMBL
      X6R6T9

    5. XM_054365620.1 → XP_054221595.1  fucose mutarotase isoform X2

    6. XM_054365619.1 → XP_054221594.1  fucose mutarotase isoform X1

    7. XM_054365623.1 → XP_054221598.1  fucose mutarotase isoform X5

    8. XM_054365624.1 → XP_054221599.1  fucose mutarotase isoform X6

    9. XM_054365626.1 → XP_054221601.1  fucose mutarotase isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VDF0.2 GenPept UniProtKB/Swiss-Prot:A2VDF0

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