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    TBC1D1 TBC1 domain family member 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282704, updated on 10-Oct-2024

    Summary

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    Official Symbol
    TBC1D1provided by VGNC
    Official Full Name
    TBC1 domain family member 1provided by VGNC
    Primary source
    VGNC:VGNC:35623
    See related
    BGD:BT19719; Ensembl:ENSBTAG00000013699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TBC1D1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (57203557..57429961)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene lysosomal-associated transmembrane protein 4B-like Neighboring gene phosphoglucomutase 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene uncharacterized LOC132345499 Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene uncharacterized LOC132345498 Neighboring gene uncharacterized LOC104972737 Neighboring gene uncharacterized LOC112447065

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retinal targets for calmodulin include proteins implicated in synaptic transmission. Xu XZ, et al. J Biol Chem, 1998 Nov 20. PMID 9813038
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    TBC1 domain family member 1
    Names
    TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
    lyncein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166524.1 → NP_001159996.1  TBC1 domain family member 1

      See identical proteins and their annotated locations for NP_001159996.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000006
      UniProtKB/Swiss-Prot
      F1MKC9, O97790
      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Related
      ENSBTAP00000067275.1, ENSBTAT00000068505.2
      Conserved Domains (6) summary
      smart00164
      Location:794 → 1011
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam01044
      Location:588 → 753
      Vinculin; Vinculin family
      pfam11830
      Location:692 → 742
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1044 → 1164
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57203557..57429961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207835.5 → XP_005207892.1  TBC1 domain family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M1P0, A0A3Q1MSW4
      Related
      ENSBTAP00000073240.2, ENSBTAT00000083632.2
      Conserved Domains (5) summary
      smart00164
      Location:888 → 1105
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:786 → 836
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1138 → 1258
      Angiomotin_C; Angiomotin C terminal

    2. XM_059887349.1 → XP_059743332.1  TBC1 domain family member 1 isoform X3

    3. XM_005207838.5 → XP_005207895.1  TBC1 domain family member 1 isoform X4

      See identical proteins and their annotated locations for XP_005207895.1

      UniProtKB/Swiss-Prot
      F1MKC9, O97790
      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Related
      ENSBTAP00000018206.4, ENSBTAT00000018206.6
      Conserved Domains (6) summary
      smart00164
      Location:794 → 1011
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam01044
      Location:588 → 753
      Vinculin; Vinculin family
      pfam11830
      Location:692 → 742
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1044 → 1164
      Angiomotin_C; Angiomotin C terminal

    4. XM_005207836.5 → XP_005207893.1  TBC1 domain family member 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Conserved Domains (5) summary
      smart00164
      Location:875 → 1092
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:773 → 823
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1125 → 1245
      Angiomotin_C; Angiomotin C terminal

    5. XM_005207839.5 → XP_005207896.1  TBC1 domain family member 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Conserved Domains (5) summary
      smart00164
      Location:781 → 998
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:679 → 729
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1031 → 1151
      Angiomotin_C; Angiomotin C terminal

    6. XM_005207841.5 → XP_005207898.1  TBC1 domain family member 1 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Conserved Domains (4) summary
      smart00164
      Location:888 → 1078
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:786 → 836
      DUF3350; Domain of unknown function (DUF3350)

    7. XM_010806056.4 → XP_010804358.1  TBC1 domain family member 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1M1P0
      Conserved Domains (4) summary
      smart00164
      Location:888 → 1078
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd00934
      Location:21 → 150
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
      cd01269
      Location:164 → 368
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:786 → 836
      DUF3350; Domain of unknown function (DUF3350)

    8. XM_024993032.2 → XP_024848800.1  TBC1 domain family member 1 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1M087, A0A3Q1MAG3
      Related
      ENSBTAP00000061372.2, ENSBTAT00000076984.2
      Conserved Domains (5) summary
      smart00164
      Location:696 → 913
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:66 → 270
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      TIGR04211
      Location:962 → 1052
      SH3_and_anchor; SH3 domain protein
      pfam01044
      Location:490 → 655
      Vinculin; Vinculin family
      pfam11830
      Location:594 → 644
      DUF3350; Domain of unknown function (DUF3350)

    9. XM_005207840.5 → XP_005207897.1  TBC1 domain family member 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MAG3
      Related
      ENSBTAP00000071005.2, ENSBTAT00000076798.2
      Conserved Domains (4) summary
      smart00164
      Location:759 → 976
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:35 → 239
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      pfam11830
      Location:657 → 707
      DUF3350; Domain of unknown function (DUF3350)
      pfam12240
      Location:1009 → 1129
      Angiomotin_C; Angiomotin C terminal

    10. XM_024993033.2 → XP_024848801.1  TBC1 domain family member 1 isoform X10

      UniProtKB/TrEMBL
      A0A3Q1MAG3
      Conserved Domains (5) summary
      smart00164
      Location:665 → 882
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01269
      Location:35 → 239
      PTB_TBC1D1_like; TBC1 domain family member 1 and related proteins Phosphotyrosine-binding (PTB) domain
      TIGR04211
      Location:931 → 1021
      SH3_and_anchor; SH3 domain protein
      pfam01044
      Location:459 → 624
      Vinculin; Vinculin family
      pfam11830
      Location:563 → 613
      DUF3350; Domain of unknown function (DUF3350)

    11. XM_010806057.4 → XP_010804359.1  TBC1 domain family member 1 isoform X11

      See identical proteins and their annotated locations for XP_010804359.1

      Conserved Domains (2) summary
      smart00164
      Location:61 → 278
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam12240
      Location:311 → 431
      Angiomotin_C; Angiomotin C terminal

    12. XM_024993034.2 → XP_024848802.1  TBC1 domain family member 1 isoform X12

      Conserved Domains (2) summary
      TIGR04211
      Location:78 → 168
      SH3_and_anchor; SH3 domain protein
      cl02495
      Location:3 → 29
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97790.2 GenPept UniProtKB/Swiss-Prot:O97790

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