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    ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 282401, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ADAMTS2provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 2provided by VGNC
    Primary source
    VGNC:VGNC:25624
    See related
    BGD:BT11061; Ensembl:ENSBTAG00000014665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ADAMTS2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (2015432..2260679)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS4, X isoform-like Neighboring gene microRNA mir-11986 Neighboring gene zinc finger protein 354C Neighboring gene U2 spliceosomal RNA Neighboring gene zinc finger protein 879

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. Colige A, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122202, Free PMC Article
    2. Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen. Colige A, et al. J Biol Chem, 1995 Jul 14. PMID 7622483
    3. Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis. Fernandes RJ, et al. J Biol Chem, 2001 Aug 24. PMID 11408482
    4. Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V. Colige A, et al. J Biol Chem, 2005 Oct 14. PMID 16046392
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
      Title: Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 2
    Names
    ADAM-TS 2
    ADAM-TS2
    ADAMTS-2
    PC I-NP
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
    pNPI
    procollagen I N-proteinase
    procollagen I/II amino propeptide-processing enzyme
    procollagen N-endopeptidase
    NP_777056.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174631.2 → NP_777056.1  A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor

      See identical proteins and their annotated locations for NP_777056.1

      Status: PROVISIONAL

      Source sequence(s)
      X96389
      UniProtKB/Swiss-Prot
      P79331
      UniProtKB/TrEMBL
      A0AAF6Z0S6
      Related
      ENSBTAP00000019526.5, ENSBTAT00000019526.6
      Conserved Domains (5) summary
      smart00209
      Location:558 → 610
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:260 → 461
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:262 → 464
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:92 → 203
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:717 → 831
      ADAM_spacer1; ADAM-TS Spacer 1

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      2015432..2260679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79331.1 GenPept UniProtKB/Swiss-Prot:P79331

    Gene LinkOut

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