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    STAT5B signal transducer and activator of transcription 5B [ Bos taurus (domestic cattle) ]

    Gene ID: 282376, updated on 12-Oct-2024

    Summary

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    Official Symbol
    STAT5Bprovided by VGNC
    Official Full Name
    signal transducer and activator of transcription 5Bprovided by VGNC
    Primary source
    VGNC:VGNC:35373
    See related
    BGD:BT12344; Ensembl:ENSBTAG00000010125
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See STAT5B in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (42319167..42384915, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene signal transducer and activator of transcription 5A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of growth hormone on the differentiation of bovine preadipocytes into adipocytes and the role of the signal transducer and activator of transcription 5b. Zhao L, et al. J Anim Sci, 2014 May. PMID 24668956
    2. A highly polymorphic GT-repeat in the bovine STAT5B encoding gene on BTA19. Meyer L, et al. Anim Genet, 1999 Feb. PMID 10050298
    3. Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle. Usman T, et al. Anim Genet, 2015 Aug. PMID 26154111
    4. Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains. Seyfert HM, et al. J Mol Evol, 2000 Jun. PMID 10835485
    5. Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins. He Y, et al. J Dairy Res, 2011 May. PMID 21435309

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNPs in JAK2 and STAT5B are associated with mastitis susceptibility in Chinese Holstein cattle
      Title: Association study of single nucleotide polymorphisms in JAK2 and STAT5B genes and their differential mRNA expression with mastitis susceptibility in Chinese Holstein cattle.
    2. This study suggests that growth hormone inhibits the differentiation of bovine preadipocytes to adipocytes through STAT5b-dependent inhibition of C/EBPalpha and PPARgamma expression.
      Title: Effect of growth hormone on the differentiation of bovine preadipocytes into adipocytes and the role of the signal transducer and activator of transcription 5b.
    3. These results suggested that the SNPs in CD4 and STAT5b may be potential genetic markers for SCS and milk/protein yields selecting and warrant further functional research.
      Title: Association of bovine CD4 and STAT5b single nucleotide polymorphisms with somatic cell scores and milk production traits in Chinese Holsteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137362

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174617.4 → NP_777042.2  signal transducer and activator of transcription 5B

      See identical proteins and their annotated locations for NP_777042.2

      Status: PROVISIONAL

      Source sequence(s)
      BC112568
      UniProtKB/Swiss-Prot
      O77702, Q2KIP0, Q9TUM2, Q9TUM3
      UniProtKB/TrEMBL
      A0A140T878
      Related
      ENSBTAP00000012497.3, ENSBTAT00000012497.5
      Conserved Domains (4) summary
      cd10420
      Location:573 → 717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42319167..42384915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005220673.5 → XP_005220730.1  signal transducer and activator of transcription 5B isoform X1

      See identical proteins and their annotated locations for XP_005220730.1

      UniProtKB/Swiss-Prot
      O77702, Q2KIP0, Q9TUM2, Q9TUM3
      UniProtKB/TrEMBL
      A0A140T878
      Conserved Domains (4) summary
      cd10420
      Location:573 → 717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain

    2. XM_024979633.2 → XP_024835401.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      O77702, Q2KIP0, Q9TUM2, Q9TUM3
      UniProtKB/TrEMBL
      A0A140T878
      Conserved Domains (4) summary
      cd10420
      Location:573 → 717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:141 → 330
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:332 → 582
      STAT_bind; STAT protein, DNA binding domain
      pfam02865
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain

    3. XM_005220675.5 → XP_005220732.1  signal transducer and activator of transcription 5B isoform X4

      UniProtKB/Swiss-Prot
      O77702, Q2KIP0, Q9TUM2, Q9TUM3
      Conserved Domains (4) summary
      cd10420
      Location:471 → 615
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:39 → 228
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:230 → 480
      STAT_bind; STAT protein, DNA binding domain
      cl03749
      Location:1 → 23
      STAT_int; STAT protein, protein interaction domain

    4. XM_059877733.1 → XP_059733716.1  signal transducer and activator of transcription 5B isoform X3

    5. XM_059877732.1 → XP_059733715.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/TrEMBL
      A0AAA9T025
      Related
      ENSBTAP00000091027.1, ENSBTAT00000107449.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TUM3.2 GenPept UniProtKB/Swiss-Prot:Q9TUM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.