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    NFKBIA NFKB inhibitor alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 282291, updated on 4-Oct-2024

    Summary

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    Official Symbol
    NFKBIAprovided by VGNC
    Official Full Name
    NFKB inhibitor alphaprovided by VGNC
    Primary source
    VGNC:VGNC:32045
    See related
    BGD:BT10682; Ensembl:ENSBTAG00000016683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NFKBIA in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (45639614..45643009, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132343372 Neighboring gene proteasome 20S subunit alpha 6 Neighboring gene uncharacterized LOC132342138 Neighboring gene U6 spliceosomal RNA Neighboring gene INSM transcriptional repressor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-κB/p65 activation during in vitro oocyte maturation and early embryogenesis. Paciolla M, et al. Hum Reprod, 2011 May. PMID 21357606
    2. Diminished NF-kappaB activation and PDGF-B expression in glomerular endothelial cells subjected to chronic shear stress. Eng E, et al. Microvasc Res, 2003 May. PMID 12711254
    3. COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization. Taura M, et al. J Virol, 2015 Mar. PMID 25520503, Free PMC Article
    4. The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha. Sorriento D, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19008357, Free PMC Article
    5. Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2. González-Pacheco FR, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16899768

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IkappaB-alpha protein was stabilized by COMMD1, which attenuated NF-kappaB signaling during Toll-like receptor ligand and tumor necrosis factor alpha treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
      Title: COMMD1/Murr1 reinforces HIV-1 latent infection through IκB-α stabilization.
    2. NFKBIA has a role as a marker of NF-kappaB/p65 activation in the early embryo.
      Title: Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-κB/p65 activation during in vitro oocyte maturation and early embryogenesis.
    3. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
      Title: The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
    4. NF-kappaB has a role in increasing PDGF-B transcription
      Title: Diminished NF-kappaB activation and PDGF-B expression in glomerular endothelial cells subjected to chronic shear stress.
    5. AIP1 is a novel transducer in TNF-induced TRAF2-dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling
      Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128575

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor alpha
    Names
    IkappaB alpha
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045868.1 → NP_001039333.1  NF-kappa-B inhibitor alpha

      See identical proteins and their annotated locations for NP_001039333.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105484
      UniProtKB/TrEMBL
      A0AAA9TXD4, Q8WNW7
      Related
      ENSBTAP00000022183.5, ENSBTAT00000022183.7
      Conserved Domains (4) summary
      COG0666
      Location:60 → 165
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:143 → 180
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:216 → 247
      Ank; Ankyrin repeat
      pfam12796
      Location:115 → 212
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      45639614..45643009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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