IGFBP4 insulin like growth factor binding protein 4 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGFBP4provided by VGNC
Official Full Name: insulin like growth factor binding protein 4provided by VGNC
Primary source: VGNC:VGNC:30086
See related: BGD:BT18595; Ensembl:ENSBTAG00000008611
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (40672669..40684257)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGFBP4 maternal blood concentrations were lower during pregnancy than during non-pregnant cycles and synchronized control cycles. The lower IGFBP4 in maternal blood may result in an increase of free insulin-like growth factor- for local action.
Title: Serum IGFBP4 concentration decreased in dairy heifers towards day 18 of pregnancy.
follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 and -5
Title: Alterations in follicular IGFBP mRNA expression and follicular fluid IGFBP concentrations during the first follicle wave in beef heifers.

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General gene information

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Markers

IGFBP4 (e-PCR)
- UniSTS:278559

fi28b09.x1 (e-PCR)
- UniSTS:197176

Igfbp4 (e-PCR), detects polymorphism
- UniSTS:461978

CC535989 (e-PCR)
- UniSTS:476597

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables insulin-like growth factor I binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor II binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor-binding protein 4

Names: IBP-4; IGF-binding protein 4; IGFBP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174557.4 → NP_776982.1 insulin-like growth factor-binding protein 4 precursor

See identical proteins and their annotated locations for NP_776982.1

Status: PROVISIONAL

Source sequence(s)

BC140688

UniProtKB/Swiss-Prot

A5D7U8, Q05716

Related

ENSBTAP00000011361.4, ENSBTAT00000011361.5

Conserved Domains (2) summary

smart00121
Location:25 → 101

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:174 → 249

Thyroglobulin_1; Thyroglobulin type-1 repeat