HSPA1A heat shock protein family A (Hsp70) member 1A [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: HSPA1A
Gene description: heat shock protein family A (Hsp70) member 1A
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HSP70; HSPA1; HSPA2; HSPA1B; HSP70-1; HSP70-2
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (27520317..27522790, complement)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hsp70 gene is a promising candidate gene to be validated in independent cattle populations and functional studies related to cold stress resilience in cattle.
Title: Detection of functional polymorphisms in the hsp70 gene and association with cold stress response in Inner-Mongolia Sanhe cattle.
In vitro acute heat stress and Geranylgeranylacetone induction increased the level of Hsp70 which upregulated the expression of TLR2/4 and NOD1/2 in both the cell cultured models. However, the expression level of TLR4 was found to be highest followed by NOD2, TLR2 and NOD1.
Title: Small interfering RNA based knock down of acute heat shock and or GGA inducible bovine heat shock protein 70 may interfere invitro expression pattern of TLR2/4 and NOD1/2.
Five novel SNPs located in the 3' flanking region of the inducible bovine HSP70A1A gene were identified in a Chinese Holstein population.
Title: Association analysis of HSP70A1A haplotypes with heat tolerance in Chinese Holstein cattle.
This study showed that Hsp70 concentration is a reliable indicator of chronic stress but is not a reliable indicator of a single stressor when animals are exposed to multiple chronic stressors.
Title: Effects of chronic heat stress on plasma concentration of secreted heat shock protein 70 in growing feedlot cattle.
the promoter region of bovine hsp70.1 gene is polymorphic and may be useful in selection of dairy cows for relatively better thermotolerance and higher milk production.
Title: Promoter variants at AP2 box region of Hsp70.1 affect thermal stress response and milk production traits in Frieswal cross bred cattle.
that HSC70 preconditioning (1) attenuates the TNF-alpha response to endotoxin in macrophages in vitro, (2) induces cardiac functional tolerance to endotoxin and (3) reduces NF-kappaB activity, and TNF-alpha and ICAM-1 levels in heart tissue.
Title: Extracellular heat shock cognate protein 70 induces cardiac functional tolerance to endotoxin: differential effect on TNF-alpha and ICAM-1 levels in heart tissue.
the presence of SNPs (C/- and G/T) in the 5'-UTR region of inducible Hsp70.1 ameliorates HS response and tolerance to heat of bovine peripheral blood mononuclear cells
Title: Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows.
The effect of culture conditions on expression of heat shock protein 70 and Bax protein in bovine blastocysts is reported.
Title: Preimplantation development and expression of Hsp-70 and Bax genes in bovine blastocysts derived from oocytes matured in alpha-MEM supplemented with growth factors and synthetic macromolecules.
protects glutamatergic synaptic transmission in olfactory cortex cells, against acute anoxia
Title: Heat-shock protein (Hsp70) protects glutamatergic synaptic transmission in cells of the rat olfactory cortex against acute anoxia in vitro.
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.
Title: Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

PMC314357P1 (e-PCR)
- UniSTS:272944

HSP70-1ALU (e-PCR), detects polymorphism
- UniSTS:250724

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables misfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mitotic spindle assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in vesicle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: heat shock 70 kDa protein 1B

Names: 70 kda heat shock protein-2; HSP70.1; HSP70.2; Heat Shock Protein 70; chaperone; heat shock 70 kD protein 1; heat shock 70 kD protein 2; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 2; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; heat-shock 70-kilodalton protein 1A; heat-shock 70-kilodalton protein 1B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203322.3 → NP_976067.3 heat shock 70 kDa protein 1B

Status: VALIDATED

Source sequence(s)

NKLS02000023

UniProtKB/Swiss-Prot

Q27964, Q27975, Q6DLW1, Q7YQF7

UniProtKB/TrEMBL

A0A5A4UBP5

Conserved Domains (1) summary

PTZ00009
Location:1 → 611

PTZ00009; heat shock 70 kDa protein; Provisional