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    DNASE1 deoxyribonuclease 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282217, updated on 10-Oct-2024

    Summary

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    Official Symbol
    DNASE1provided by VGNC
    Official Full Name
    deoxyribonuclease 1provided by VGNC
    Primary source
    VGNC:VGNC:28132
    See related
    BGD:BT26610; Ensembl:ENSBTAG00000020107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DNASE1 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (2981353..2999607)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene NLR family CARD domain containing 3 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene microRNA mir-2383 Neighboring gene TNF receptor associated protein 1 Neighboring gene uncharacterized LOC101903988 Neighboring gene CREB binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing and expression of a cDNA encoding bovine pancreatic deoxyribonuclease I in Escherichia coli: purification and characterization of the recombinant enzyme. Chen CY, et al. Gene, 1998 Jan 12. PMID 9469931
    2. Bovine pancreatic deoxyribonuclease A. Isolation of cyanogen bromide peptides; complete covalent structure of the polypeptide chain. Liao TH, et al. J Biol Chem, 1992 Apr 15. PMID 1348510
    3. X-ray structure of the DNase I-d(GGTATACC)2 complex at 2.3 A resolution. Weston SA, et al. J Mol Biol, 1992 Aug 20. PMID 1518054
    4. Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I. Suck D, et al. Nature, 1988 Mar 31. PMID 3352748
    5. Crystallographic refinement and structure of DNase I at 2 A resolution. Oefner C, et al. J Mol Biol, 1986 Dec 5. PMID 3560229

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ascorbic acid has the ability to inhibit DNase I, one of the main endonucleases involved in DNA fragmentation during apoptosis.
      Title: Ascorbic acid as DNase I inhibitor in prevention of male infertility.
    2. the practical capability of this assay system was successfully demonstrated by its use to determine DNase I activity in bovine urine.
      Title: A label-free fluorescent assay for deoxyribonuclease I activity based on DNA-templated silver nanocluster/graphene oxide nanocomposite.
    3. Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes.
      Title: Sequence-dependent DNA flexibility mediates DNase I cleavage.
    4. results indicated that the backbone hydrogen bonding in the antiparallel beta-sheet formed by its N- and C-termini, rather than the side-chain interactions, is crucial for the correct protein folding
      Title: Involvement of the N- and C-terminal fragments of bovine pancreatic deoxyribonuclease in active protein folding.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    deoxyribonuclease-1
    Names
    DNase I
    deoxyribonuclease I
    NP_776959.1
    XP_024840423.1
    XP_024840425.1
    XP_024840426.1
    XP_024840427.1
    XP_059737140.1
    XP_059737141.1
    XP_059737142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174534.2 → NP_776959.1  deoxyribonuclease-1 precursor

      See identical proteins and their annotated locations for NP_776959.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ001538
      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27
      UniProtKB/TrEMBL
      Q9GL62, Q9GL63
      Related
      ENSBTAP00000026784.3, ENSBTAT00000026784.4
      Conserved Domains (1) summary
      smart00476
      Location:24 → 282
      DNaseIc; deoxyribonuclease I

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      2981353..2999607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881158.1 → XP_059737141.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27

    2. XM_024984657.2 → XP_024840425.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27
      UniProtKB/TrEMBL
      Q9GL62, Q9GL63
      Conserved Domains (1) summary
      smart00476
      Location:24 → 282
      DNaseIc; deoxyribonuclease I

    3. XM_059881157.1 → XP_059737140.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27

    4. XM_059881159.1 → XP_059737142.1  deoxyribonuclease-1 isoform X2

    5. XM_024984658.2 → XP_024840426.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27
      UniProtKB/TrEMBL
      Q9GL62, Q9GL63
      Conserved Domains (1) summary
      smart00476
      Location:24 → 282
      DNaseIc; deoxyribonuclease I

    6. XM_024984659.2 → XP_024840427.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27
      UniProtKB/TrEMBL
      Q9GL62, Q9GL63
      Conserved Domains (1) summary
      smart00476
      Location:24 → 282
      DNaseIc; deoxyribonuclease I

    7. XM_024984655.2 → XP_024840423.1  deoxyribonuclease-1 isoform X1

      UniProtKB/Swiss-Prot
      A5PK44, P00639, Q8MJ27
      UniProtKB/TrEMBL
      Q9GL62, Q9GL63
      Conserved Domains (1) summary
      smart00476
      Location:24 → 282
      DNaseIc; deoxyribonuclease I
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00639.3 GenPept UniProtKB/Swiss-Prot:P00639

    Gene LinkOut

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    Research Materials