CSN1S1 casein alpha s1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CSN1S1provided by VGNC
Official Full Name: casein alpha s1provided by VGNC
Primary source: VGNC:VGNC:27763
See related: BGD:BT11562; Ensembl:ENSBTAG00000007695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CSN1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (85411718..85429255)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of genomic regions associated with alphaS1-casein phosphorylation.
Title: Genome-wide association study for α(S1)- and α(S2)-casein phosphorylation in Dutch Holstein Friesian.
There were no associations between x genotype and fertility related traits in this study.
Title: Estimates of epistatic and pleiotropic effects of () and () genetic markers on beef heifer performance traits enhanced by selection.
The results give insight in phosphorylation of alpha(S1)-CN-8P and alpha(S1)-CN-9P, which seem to be regulated by a different set of genes.
Title: Phosphorylation of αS1-casein is regulated by different genes.
Report proteomic detection of bovine alpha-S1-casein in term and preterm human colostrum.
Title: Detection of bovine alpha-S1-casein in term and preterm human colostrum with proteomic techniques.
Data indicate that the pepsin-pancreatin digest of alphaS-Casein exhibited anxiolytic-like activity.
Title: Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.
The genetic effects of thyroglobulin and casein alpha s1 alpha in the body fat distribution of cattle are reported.
Title: Selection for genetic markers in beef cattle reveals complex associations of thyroglobulin and casein1-s1 with carcass and meat traits.
Alpha-S2-casein was less effective at preventing fibril formation by modified kappa-casein, whereas alpha- and alpha-S1 casein were comparably potent inhibitors.
Title: The chaperone action of bovine milk αS1- and αS2-caseins and their associated form αS-casein.
Substitution effects of paternal CSN2alpha (s1) allele versus CSN2 alpha(s2) allele on protein yield deviations (YDs) are significant, whereas their effects on milk and fat YDs are not.
Title: Associations between 2 paternal casein haplotypes and milk yield traits of Swiss Fleckvieh cattle.
An isoelectrofocusing pattern was identified, which may result from a novel CSN1S1 variant, named CSN1S1*I, migrating at an intermediate position between CSN1S1*B and CSN1S1*C.
Title: Short communication: Carora cattle show high variability in alpha(s1)-casein.
EMSA analysis comparing allelic variants of a polymorphic AP-1 binding site in the promoter region of CSN1S1; specific and reduced protein binding of oligonucleotides containing the G variant of the CSN1S1-175bp binding site was shown
Title: Polymorphic AP-1 binding site in bovine CSN1S1 shows quantitative differences in protein binding associated with milk protein expression.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CSN1S1 (e-PCR), detects polymorphism
- UniSTS:253703

CSN1S1 (e-PCR), detects polymorphism
- UniSTS:279537

Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in response to 11-deoxycorticosterone	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to dehydroepiandrosterone	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to progesterone	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alpha-S1-casein

Names: casein alpha-S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.