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    COL1A1 collagen type I alpha 1 chain [ Bos taurus (domestic cattle) ]

    Gene ID: 282187, updated on 4-Oct-2024

    Summary

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    Official Symbol
    COL1A1provided by VGNC
    Official Full Name
    collagen type I alpha 1 chainprovided by VGNC
    Primary source
    VGNC:VGNC:27560
    See related
    BGD:BT10494; Ensembl:ENSBTAG00000013103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See COL1A1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (36457711..36474476)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 92 Neighboring gene histone H2B type 1-C/E/F/G/I Neighboring gene sarcoglycan alpha Neighboring gene H1.9 linker histone Neighboring gene protein phosphatase 1 regulatory subunit 9B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The aggregation behavior of native collagen in dilute solution studied by intrinsic fluorescence and external probing. Wu K, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2013 Feb. PMID 23220534
    2. Delay of cell cycle progression and induction death of cancer cells on type I collagen fibrils [corrected]. Sasaki J, et al. Connect Tissue Res, 2011 Jun. PMID 20672981
    3. Verification of simple hydration/dehydration methods to characterize multiple water compartments on tendon type 1 collagen. Cameron IL, et al. Cell Biol Int, 2007 Jun. PMID 17363297
    4. OIM and related animal models of osteogenesis imperfecta. Shapiro JR, et al. Connect Tissue Res, 1995. PMID 15612365
    5. The amino acid sequence of the carboxyterminal nonhelical cross link region of the alpha 1 chain of calf skin collagen. Rauterberg J, et al. FEBS Lett, 1972 Mar. PMID 11946479

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present findings suggest that prolyl 3-hydroxylation incrementally regulates collagen fibril diameter in tendon.
      Title: Developmental Stage-dependent Regulation of Prolyl 3-Hydroxylation in Tendon Type I Collagen.
    2. These observations support a signaling network among JNKs, Smads, Snail1, and cortactin to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents.
      Title: Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation.
    3. The experiment results demonstrated that the aggregates of collagen incurred in the range of 0.30-0.45 mg/mL, while the more complicated ones emerged at higher concentrations of collagen (0.75 and 1.05 mg/mL).
      Title: The aggregation behavior of native collagen in dilute solution studied by intrinsic fluorescence and external probing.
    4. Two subsystems of meniscal collagen and their different thermal stabilities.
      Title: Two subsystems of meniscal collagen and their different thermal stabilities.
    5. These results imply that the fibril form of collagen plays a potential role in inhibiting the growth of cancer cells.
      Title: Delay of cell cycle progression and induction death of cancer cells on type I collagen fibrils [corrected].
    6. Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude.
      Title: Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi.
    7. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
      Title: Matrix-specific suppression of integrin activation in shear stress signaling.
    8. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen
      Title: Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells.
    9. A molecular model of collagen hydration is used to validate centrifugal dehydration force (CDF) and re-hydration isotherm (RHI) methods to measure and characterize hydration compartments on bovine tendon.
      Title: Verification of simple hydration/dehydration methods to characterize multiple water compartments on tendon type 1 collagen.
    10. These results demonstrate a novel and important functional role of the DDR2 extracellular domain that may contribute to collagen regulation via modulation of fibrillogenesis.
      Title: Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC128258

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    collagen alpha-1(I) chain
    Names
    alpha-1 type I collagen
    collagen, type I, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034039.2 → NP_001029211.1  collagen alpha-1(I) chain precursor

      See identical proteins and their annotated locations for NP_001029211.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105184
      UniProtKB/Swiss-Prot
      P02453, Q3MHM2
      Related
      ENSBTAP00000017420.3, ENSBTAT00000017420.5
      Conserved Domains (5) summary
      pfam01391
      Location:235 → 294
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00093
      Location:40 → 95
      VWC; von Willebrand factor type C domain
      pfam01410
      Location:1229 → 1462
      COLFI; Fibrillar collagen C-terminal domain
      cl26386
      Location:448 → 639
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
      cl28310
      Location:904 → 1110
      Rho; Transcription termination factor Rho [Transcription]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36457711..36474476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02453.3 GenPept UniProtKB/Swiss-Prot:P02453

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.