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    ANGPT1 angiopoietin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282140, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ANGPT1provided by VGNC
    Official Full Name
    angiopoietin 1provided by VGNC
    Primary source
    VGNC:VGNC:53848
    See related
    BGD:BT17993; Ensembl:ENSBTAG00000014051
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ANGPT1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (56815170..57287107)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene R-spondin 2 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene intraflagellar transport 27 homolog pseudogene Neighboring gene developmentally regulated GTP binding protein 1 pseudogene Neighboring gene uncharacterized LOC132342163 Neighboring gene TBC1 domain family member 1-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Tekari A, et al. Stem Cell Res Ther, 2016 May 23. PMID 27216150, Free PMC Article
    2. Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows. Hayashi KG, et al. J Reprod Dev, 2004 Aug. PMID 15329480
    3. Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Goede V, et al. Lab Invest, 1998 Nov. PMID 9840613
    4. Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro. Oubaha M, et al. Blood, 2009 Oct 8. PMID 19564638
    5. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Mandriota SJ, et al. Circ Res, 1998 Oct 19. PMID 9776732

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
      Title: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
    2. inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1.
      Title: Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro.
    3. ANPT-1 becomes predominant in the follicle producing high levels of E(2), indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist).
      Title: Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143440

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Tie signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    angiopoietin-1
    Names
    ANG-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076797.1 → NP_001070265.1  angiopoietin-1 precursor

      See identical proteins and their annotated locations for NP_001070265.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123628
      UniProtKB/Swiss-Prot
      O18920, Q08DP8
      UniProtKB/TrEMBL
      A0AAA9S7X2
      Related
      ENSBTAP00000018675.7, ENSBTAT00000018675.7
      Conserved Domains (2) summary
      cd00087
      Location:280 → 495
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      TIGR04523
      Location:80 → 258
      Mplasa_alph_rch; helix-rich Mycoplasma protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56815170..57287107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059893126.1 → XP_059749109.1  angiopoietin-1 isoform X1

    2. XM_059893127.1 → XP_059749110.1  angiopoietin-1 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TLI4
      Related
      ENSBTAP00000097799.1, ENSBTAT00000118514.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18920.3 GenPept UniProtKB/Swiss-Prot:O18920

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.