RPE65 retinoid isomerohydrolase RPE65 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: RPE65provided by VGNC
Official Full Name: retinoid isomerohydrolase RPE65provided by VGNC
Primary source: VGNC:VGNC:34101
See related: BGD:BT29691; Ensembl:ENSBTAG00000020494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (76830541..76853872)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function.
Title: The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function.
Data indicate that Structural differences between delipidated and nondelipidated RPE65 uncovered key residues involved in substrate uptake and processing.
Title: Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.
oxidative stress during the visual cycle results in cleavage of RPE65
Title: Cleavage of the retinal pigment epithelium-specific protein RPE65 under oxidative stress.
the enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment
Title: Importance of membrane structural integrity for RPE65 retinoid isomerization activity.
Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
Title: Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.
RPE65 from the cone-dominant chicken RPE possesses significantly higher specific retinol isomerohydrolase activity, when compared with RPE65 from rod-dominant species
Title: RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species.
LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 with membranes is neither dependent upon LRAT nor the result of S-palmitoylation
Title: Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
Data show that RPE65 is a moderately specific retinoid binding protein directed at long chain all-trans-retinyl esters.
Title: Specificity of binding of all-trans-retinyl ester to RPE65.
retinoid binding role for RPE65
Title: A cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65.
Quenching of protein fluorescence is used to demonstrate quantitatively that RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle.
Title: RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IEA Inferred from Electronic Annotation more info	PubMed
enables beta-carotene 15,15'-dioxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables retinol isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in retinal metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in zeaxanthin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: retinoid isomerohydrolase

Names: RPE65, retinoid isomerohydrolase; all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein (65kD); retinal pigment epithelium-specific protein 65kDa; retinol isomerase

NP_776878.1

EC 3.1.1.64

EC 5.3.3.22

XP_059737655.1

EC 3.1.1.64

EC 5.3.3.22

XP_059737659.1

EC 3.1.1.64

EC 5.3.3.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.