PROS1 protein S [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PROS1provided by VGNC
Official Full Name: protein Sprovided by VGNC
Primary source: VGNC:VGNC:49565
See related: BGD:BT18685; Ensembl:ENSBTAG00000023652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	1	NC_037328.1 (38203318..38267163, complement)

Chromosome 1 - NC_037328.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activated protein C(APC) combined with protein S(PS) had significant antithrombotic effect. APC combined with PS prolonged clotting time. Dependence on APC-cofactor activity of PS for expression of anticoagulant activity by APC.
Title: Prevention of thrombosis following deep arterial injury in rats by bovine activated protein C requiring co-administration of bovine protein S.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vitamin K-dependent protein S

Names: protein S (alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174438.1 → NP_776863.1 vitamin K-dependent protein S precursor

See identical proteins and their annotated locations for NP_776863.1

Status: PROVISIONAL

Source sequence(s)

M13044

UniProtKB/Swiss-Prot

P07224

UniProtKB/TrEMBL

A0A3Q1NAF6

Related

ENSBTAP00000032310.4, ENSBTAT00000032377.5

Conserved Domains (7) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

pfam00008
Location:121 → 152

EGF; EGF-like domain

pfam00054
Location:329 → 459

Laminin_G_1; Laminin G domain

pfam02210
Location:514 → 646

Laminin_G_2; Laminin G domain

pfam06247
Location:134 → 287

Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28

pfam07645
Location:201 → 241

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:168 → 199

FXa_inhibition; Coagulation Factor Xa inhibitory site