PRDX3 peroxiredoxin 3 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PRDX3provided by VGNC
Official Full Name: peroxiredoxin 3provided by VGNC
Primary source: VGNC:VGNC:33301
See related: BGD:BT23849; Ensembl:ENSBTAG00000008731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MTAP
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (39330338..39339692, complement)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of AOP-1 is induced; this effect may be involved in inhibition of apoptosis in infected blastocysts/embryos.
Title: Evaluation of developmental changes in bovine in vitro produced embryos following exposure to bovine Herpesvirus type 5.
PRDX3, also known as SP-22, is a mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid
Title: Structure-function analysis of recombinant substrate protein 22 kDa (SP-22). A mitochondrial 2-CYS peroxiredoxin organized as a decameric toroid.

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General gene information

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Markers

PRDX3-1 (e-PCR)
- UniSTS:512648

PRDX3 (e-PCR)
- UniSTS:278951

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: thioredoxin-dependent peroxide reductase, mitochondrial

Names: 5'-methylthioadenosine phosphorylase; AOP-1; MTA phosphorylase; MTAPase; antioxidant protein 1; thioredoxin-dependent peroxiredoxin 3

NP_776857.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174432.2 → NP_776857.1 thioredoxin-dependent peroxide reductase, mitochondrial precursor

See identical proteins and their annotated locations for NP_776857.1

Status: PROVISIONAL

Source sequence(s)

D82025

UniProtKB/Swiss-Prot

P35705, Q3SZA8

UniProtKB/TrEMBL

A0AAA9SN98

Related

ENSBTAP00000011505.1, ENSBTAT00000011505.3

Conserved Domains (2) summary

PTZ00253
Location:70 → 256

PTZ00253; tryparedoxin peroxidase; Provisional

cd03015
Location:66 → 236

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...