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    ITGAV integrin subunit alpha V [ Bos taurus (domestic cattle) ]

    Gene ID: 281875, updated on 4-Oct-2024

    Summary

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    Official Symbol
    ITGAVprovided by VGNC
    Official Full Name
    integrin subunit alpha Vprovided by VGNC
    Primary source
    VGNC:VGNC:30323
    See related
    BGD:BT24336; Ensembl:ENSBTAG00000019929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ITGAV in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (9640553..9749414, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 2 Neighboring gene family with sequence similarity 171 member B Neighboring gene microRNA mir-2351 Neighboring gene small integral membrane protein 20-like Neighboring gene uncharacterized LOC132342943 Neighboring gene transfer RNA glycine (anticodon UCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-efficiency utilization of the bovine integrin alpha(v)beta(3) as a receptor for foot-and-mouth disease virus is dependent on the bovine beta(3) subunit. Neff S, et al. J Virol, 2000 Aug. PMID 10906183, Free PMC Article
    2. Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness. Dicara D, et al. J Virol, 2008 Feb. PMID 18045932, Free PMC Article
    3. Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains. Andersen MH, et al. Biochemistry, 1997 May 6. PMID 9154926
    4. Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability. Ganter MT, et al. Am J Respir Cell Mol Biol, 2009 Jan. PMID 18703797, Free PMC Article
    5. Interactions of foot-and-mouth disease virus with soluble bovine alphaVbeta3 and alphaVbeta6 integrins. Duque H, et al. J Virol, 2004 Sep. PMID 15331710, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
      Title: Matrix-specific suppression of integrin activation in shear stress signaling.
    2. These results demonstrate the critical role of the RhoA/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
      Title: Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability.
    3. specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.
      Title: Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness.
    4. identified as receptor for foot-and-mouth disease virus
      Title: Interactions of foot-and-mouth disease virus with soluble bovine alphaVbeta3 and alphaVbeta6 integrins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159480

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin alpha-V
    Names
    integrin alpha V subunit
    integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
    vitronectin receptor subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174367.1 → NP_776792.1  integrin alpha-V precursor

      See identical proteins and their annotated locations for NP_776792.1

      Status: PROVISIONAL

      Source sequence(s)
      AF239958
      UniProtKB/Swiss-Prot
      P80746, Q0PDN6, Q9GK48, Q9MZD6
      Related
      ENSBTAP00000083933.1, ENSBTAT00000092224.1
      Conserved Domains (4) summary
      smart00191
      Location:366 → 420
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:466 → 913
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:220 → 270
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
      sd00039
      Location:51 → 119
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      9640553..9749414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202252.5 → XP_005202309.1  integrin alpha-V isoform X1

      UniProtKB/Swiss-Prot
      P80746, Q0PDN6, Q9GK48, Q9MZD6
      UniProtKB/TrEMBL
      A0A3Q1MXS2, A0AAA9SEW0
      Related
      ENSBTAP00000060618.1, ENSBTAT00000082026.2
      Conserved Domains (4) summary
      smart00191
      Location:367 → 421
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:467 → 914
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:221 → 271
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
      sd00039
      Location:51 → 120
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80746.3 GenPept UniProtKB/Swiss-Prot:P80746

    Gene LinkOut

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